FAM90A19 Gene - Function, Disease Associations, and Expression
A comprehensive overview of the FAM90A19 gene, including its genomic context, expression patterns, and potential disease relevance.
Gene Information Card
| Symbol | FAM90A19 |
|---|---|
| Full Name | family with sequence similarity 90 member A19 |
| Gene Type | protein-coding |
| Chromosomal Location | 8p23.1 |
| NCBI Gene ID | 728833 ncbi.nlm.nih.gov/gene/728833 |
| Ensembl ID | ENSG00000235169 |
| UniProt ID | A6NKF1 |
| OMIM ID | Not available |
| HGNC ID | 33866 |
| Aliases | FAM90A2P, FAM90A19P |
Description
FAM90A19 is a protein-coding gene located on chromosome 8p23.1. It belongs to the FAM90A family, which is characterized by a series of duplicated genes and pseudogenes in this region. The gene is part of a complex genomic region with multiple copies and structural variations. FAM90A19 is predicted to encode a protein with unknown function, and its expression is low across tissues. The gene has been noted in the context of genomic instability and potential involvement in disease, though specific functional studies are limited.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association | Not established | No direct evidence from curated databases |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 0.0 | Not detected |
| Brain | 0.0 | Not detected |
| Liver | 0.0 | Not detected |
| Heart | 0.0 | Not detected |
| Kidney | 0.0 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 0.0 | Not detected |
| K562 | 0.0 | Not detected |
| MCF7 | 0.0 | Not detected |
| A549 | 0.0 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No curated variants | Not applicable | Not available | No functional effect reported |
Mutation functional classification
Loss of Function (LOF)
No evidence
Gain of Function (GOF)
No evidence
Dominant Negative (DN)
No evidence
View complete mutation data：
Protein Summary
The FAM90A19 gene encodes a protein of unknown function. Based on sequence analysis, it is predicted to be a small protein with no characterized domains. The protein is not well-studied, and no experimental evidence for its cellular localization or biochemical activity is available. It is likely a member of the FAM90A family, which may be involved in genomic stability, but specific functions remain to be determined.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| FAM90A19 Knockout HEK293 Cell Line | EDJ-KQ13385 | Human | 728753 | Details Get a Quote |
| FAM90A19 Knockout A-549 Cell Line | EDJ-KQ41655 | Human | 728753 | Details Get a Quote |
| FAM90A19 Knockout HCT 116 Cell Line | EDJ-KQ42886 | Human | 728753 | Details Get a Quote |
| FAM90A19 Knockout HeLa Cell Line | EDJ-KQ42887 | Human | 728753 | Details Get a Quote |
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