FAM90A16 Gene: Function, Expression, and Clinical Significance
A comprehensive overview of the FAM90A16 gene, including its genomic context, expression patterns, and potential implications in disease.
Gene Information Card
| Symbol | FAM90A16 |
|---|---|
| Full Name | family with sequence similarity 90 member A16 |
| Gene Type | protein coding |
| Chromosomal Location | 8p23.1 |
| NCBI Gene ID | 100132417 ncbi.nlm.nih.gov/gene/100132417 |
| Ensembl ID | ENSG00000235169 |
| UniProt ID | A6NKF1 |
| OMIM ID | Not available |
| HGNC ID | 33884 |
| Aliases | FLJ46257 |
Description
FAM90A16 (family with sequence similarity 90 member A16) is a protein-coding gene located on chromosome 8p23.1. It is part of the FAM90A gene family, which is characterized by a variable number of copies in the human genome. The gene is expressed in various tissues, though its exact function remains largely uncharacterized. FAM90A16 has been noted in some studies for its potential involvement in certain cancers, but evidence is limited and further research is needed.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (general) | Potential involvement suggested by differential expression in tumor tissues; exact mechanism not established. | Limited evidence from expression studies; no direct clinical association confirmed. |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | Not available | Low expression |
| Kidney | Not available | Low expression |
| Liver | Not available | Low expression |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | Not available | Low expression |
| A549 | Not available | Low expression |
| MCF7 | Not available | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No specific variants reported | Not applicable | Not applicable | Not applicable |
Mutation functional classification
Loss of Function (LOF)
No data available.
Gain of Function (GOF)
No data available.
Dominant Negative (DN)
No data available.
View complete mutation data：
Protein Summary
The FAM90A16 protein is predicted to be a membrane-associated protein, but its exact function is unknown. It shares sequence similarity with other FAM90A family members, which are thought to be involved in cellular processes such as signal transduction or immune response, but specific roles for FAM90A16 have not been experimentally validated.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| FAM90A16 Knockout HEK293 Cell Line | EDJ-KQ13381 | Human | 441323 | Details Get a Quote |
| FAM90A16 Knockout HCT 116 Cell Line | EDJ-KQ41649 | Human | 441323 | Details Get a Quote |
| FAM90A16 Knockout A-549 Cell Line | EDJ-KQ42877 | Human | 441323 | Details Get a Quote |
| FAM90A16 Knockout HeLa Cell Line | EDJ-KQ42879 | Human | 441323 | Details Get a Quote |
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