FAM90A14 Gene: Function, Expression, and Clinical Significance
A comprehensive overview of the FAM90A14 gene, including its genomic context, expression patterns, and potential implications in disease.
Gene Information Card
| Symbol | FAM90A14 |
|---|---|
| Full Name | family with sequence similarity 90 member A14 |
| Gene Type | protein-coding |
| Chromosomal Location | 8p23.1 |
| NCBI Gene ID | 100132417 ncbi.nlm.nih.gov/gene/100132417 |
| Ensembl ID | ENSG00000235169 |
| UniProt ID | A6NMY6 |
| OMIM ID | Not available |
| HGNC ID | 33836 |
| Aliases | FLJ46257 |
Description
FAM90A14 is a protein-coding gene located on chromosome 8p23.1. It is part of the FAM90A gene family, which is characterized by a variable number of tandem repeats in the human genome. The gene encodes a protein of unknown function, but its expression has been detected in various tissues. Due to its location in a region associated with genomic instability, FAM90A14 may play a role in certain diseases, although direct evidence is limited.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Not established | No direct disease association has been confirmed for FAM90A14. | No evidence from ClinVar or COSMIC. |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | Not available | Low expression |
| Thyroid | Not available | Low expression |
| Adrenal gland | Not available | Low expression |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| No data available | Not available | No cell line expression data found. |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No curated mutations | Not available | Not available | No mutations reported in COSMIC or ClinVar. |
Mutation functional classification
Loss of Function (LOF)
No data available.
Gain of Function (GOF)
No data available.
Dominant Negative (DN)
No data available.
View complete mutation data：
Protein Summary
The FAM90A14 protein is predicted to be a small, uncharacterized protein. Its function remains unknown, and no structural or functional domains have been identified. Further research is needed to elucidate its biological role.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| FAM90A14 Knockout HEK293 Cell Line | EDJ-KQ13380 | Human | 645651 | Details Get a Quote |
| FAM90A14 Knockout A-549 Cell Line | EDJ-KQ42874 | Human | 645651 | Details Get a Quote |
| FAM90A14 Knockout HCT 116 Cell Line | EDJ-KQ42875 | Human | 645651 | Details Get a Quote |
| FAM90A14 Knockout HeLa Cell Line | EDJ-KQ42876 | Human | 645651 | Details Get a Quote |
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