FAM178B: A Little-Characterized Protein-Coding Gene
Exploring the genomic and potential functional landscape of FAM178B
Gene Information Card
| Symbol | FAM178B |
|---|---|
| Full Name | Family With Sequence Similarity 178 Member B |
| Gene Type | Protein-coding |
| Chromosomal Location | 10q26.13 |
| NCBI Gene ID | 100131257 ncbi.nlm.nih.gov/gene/100131257 |
| Ensembl ID | ENSG00000185507 |
| UniProt ID | Q5T0J0 |
| OMIM ID | Not assigned |
| HGNC ID | 33777 |
| Aliases | MGC16384, bA155J5.1 |
Description
FAM178B is a protein-coding gene located on chromosome 10q26.13. It encodes a protein of unknown function, with no established disease associations or detailed functional characterization in current literature. The gene is conserved in vertebrates and is expressed at low levels in various tissues.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No known disease associations | Not applicable | No evidence in ClinVar, OMIM, or COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 0.8 | Low |
| Brain | 0.5 | Low |
| Lung | 0.3 | Low |
| Liver | 0.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 0.6 | Low expression |
| HeLa | 0.4 | Low expression |
| K562 | 0.3 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No reported variants in COSMIC or ClinVar | Not applicable | Not applicable | Not applicable |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Protein Summary
The FAM178B protein (UniProt Q5T0J0) is 346 amino acids long with no characterized domains or known function. It is predicted to be intracellular, but no experimental data on its localization or interactions are available.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| FAM178B Knockout HEK293 Cell Line | EDJ-KQ10288 | Human | 51252 | Details Get a Quote |
| FAM178B Knockout HeLa Cell Line | EDJ-KQ56261 | Human | 51252 | Details Get a Quote |
| FAM178B Knockout A-549 Cell Line | EDJ-KQ64750 | Human | 51252 | Details Get a Quote |
| FAM178B Knockout HCT 116 Cell Line | EDJ-KQ73196 | Human | 51252 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
