FAM110C Gene: Function, Location, and Disease Associations | Biomedical Hub

FAM110C (Family With Sequence Similarity 110 Member C) is a protein-coding gene located on the short arm of chromosome 2 (2p25.3). It belongs to the FAM110 family, which also includes FAM110A and FAM110B. The encoded protein is characterized by a C-terminal coiled-coil domain and is known to localize to the centrosome and mitotic spindle during cell division. FAM110C is thought to play a role in cell cycle progression and cytoskeletal organization. While its precise functions are still being characterized, emerging evidence suggests it may be involved in the regulation of microtubule dynamics and potentially in the pathogenesis of certain cancers. The gene is expressed in various tissues, with notable levels in the brain, testis, and some cancer cell lines.

Tissue Expression

Cell Line Expression

Hotspot Mutations

Mutation functional classification

• Cell Cycle

• Mitotic

• Resolution of Sister Chromatid Cohesion

• Microtubule cytoskeleton organization

The FAM110C protein is a 307-amino acid polypeptide with a predicted molecular mass of approximately 34 kDa. It contains a coiled-coil domain in its C-terminal region, which is a common motif for protein-protein interactions. Immunofluorescence studies have shown that FAM110C localizes to the centrosome during interphase and to the mitotic spindle during mitosis, suggesting a role in cell division. It is believed to interact with other centrosomal and spindle-associated proteins, potentially influencing microtubule dynamics and chromosome segregation. The protein is expressed at low levels in most normal tissues but shows elevated expression in some cancer cell lines, hinting at a possible role in oncogenesis. However, the exact molecular mechanisms and binding partners of FAM110C remain largely unknown and are the subject of ongoing research.