ELF3 (E74 Like ETS Transcription Factor 3)
A key epithelial-specific transcription factor involved in development, differentiation, and cancer.
Gene Information Card
| Symbol | ELF3 |
|---|---|
| Full Name | E74 Like ETS Transcription Factor 3 |
| Gene Type | Protein coding |
| Chromosomal Location | 1q21.3 |
| NCBI Gene ID | 1999 ncbi.nlm.nih.gov/gene/1999 |
| Ensembl ID | ENSG00000163435 |
| UniProt ID | P78545 |
| OMIM ID | 602191 |
| HGNC ID | 3318 |
| Aliases | EPR-1, ESX, ERT, ETS-related transcription factor |
Description
ELF3 (E74 Like ETS Transcription Factor 3) is a member of the ETS family of transcription factors. It is specifically expressed in epithelial cells and plays a critical role in regulating genes involved in epithelial cell differentiation, proliferation, and barrier function. ELF3 binds to DNA sequences containing the core consensus motif 5'-GGAA-3' and acts as both a transcriptional activator and repressor. It is implicated in development of the mammary gland, prostate, lung, and intestine, and its dysregulation is associated with various cancers, including breast, prostate, and colorectal cancer.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | ELF3 overexpression promotes cell proliferation and invasion; acts as an oncogene in luminal subtypes. | ClinVar, COSMIC, PMID: 25691885 |
| Prostate cancer | ELF3 is frequently amplified and overexpressed, driving androgen receptor signaling and tumor progression. | COSMIC, PMID: 23382250 |
| Colorectal cancer | Loss of ELF3 expression correlates with poor prognosis; may function as a tumor suppressor in some contexts. | ClinVar, PMID: 27562873 |
| Lung adenocarcinoma | ELF3 mutations and altered expression contribute to epithelial-mesenchymal transition and metastasis. | COSMIC, PMID: 29348524 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 45.2 | High |
| Prostate | 38.7 | High |
| Breast | 32.1 | High |
| Colon | 28.5 | Medium |
| Kidney | 12.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 (breast cancer) | 62.4 | High expression; luminal subtype |
| PC3 (prostate cancer) | 55.8 | High expression; androgen-independent |
| A549 (lung cancer) | 48.9 | Moderate expression |
| HT29 (colorectal cancer) | 22.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| p.Glu81Lys | Missense | 0.2% | Alters DNA-binding affinity; potential gain-of-function |
| p.Arg232* | Nonsense | 0.1% | Truncation; loss-of-function |
| p.Ser207Leu | Missense | 0.3% | Reduced transcriptional activity |
| Amplification | Copy number gain | 5-10% in prostate cancer | Overexpression; oncogenic |
Mutation functional classification
Loss of Function (LOF)
Nonsense and frameshift mutations (e.g., p.Arg232*) lead to truncated protein lacking transactivation domain, reducing target gene activation.
Gain of Function (GOF)
Missense mutations in the ETS domain (e.g., p.Glu81Lys) can enhance DNA binding and transcriptional activity, promoting oncogenic signaling.
Dominant Negative (DN)
Some missense mutations in the DNA-binding domain may produce proteins that compete with wild-type ELF3, inhibiting normal function.
View complete mutation data：
Gene Ontology (GO)
Pathways
• ETS family transcription factor pathway
• Epithelial cell signaling in cancer
• Androgen receptor signaling pathway
• EGFR signaling pathway
Protein Summary
The ELF3 protein (UniProt P78545) is a 371-amino acid transcription factor containing a conserved ETS DNA-binding domain. It localizes to the nucleus and regulates expression of genes involved in epithelial differentiation, cell cycle, and apoptosis. Post-translational modifications include phosphorylation, which modulates its activity. ELF3 interacts with co-regulators such as p300 and HDAC1 to fine-tune transcriptional output.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ELF3 Knockout HEK293 Cell Line | EDJ-KQ2223 | Human | 1999 | Details Get a Quote |
| ELF3 Knockout A-549 Cell Line | EDJ-KQ22500 | Human | 1999 | Details Get a Quote |
| ELF3 Knockout HCT 116 Cell Line | EDJ-KQ22501 | Human | 1999 | Details Get a Quote |
| ELF3 Knockout HeLa Cell Line | EDJ-KQ22502 | Human | 1999 | Details Get a Quote |
| CELF3 Knockout HEK293 Cell Line | EDJ-KQ51052 | Human | 11189 | Details Get a Quote |
| CELF3 Knockout HeLa Cell Line | EDJ-KQ55599 | Human | 11189 | Details Get a Quote |
| CELF3 Knockout A-549 Cell Line | EDJ-KQ64095 | Human | 11189 | Details Get a Quote |
| CELF3 Knockout HCT 116 Cell Line | EDJ-KQ72545 | Human | 11189 | Details Get a Quote |
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