EIF4E1B: Eukaryotic Translation Initiation Factor 4E Family Member 1B
A member of the EIF4E family involved in cap-dependent translation initiation, with potential roles in germ cell development and cancer.
Gene Information Card
| Symbol | EIF4E1B |
|---|---|
| Full Name | Eukaryotic Translation Initiation Factor 4E Family Member 1B |
| Gene Type | Protein-coding |
| Chromosomal Location | 5q35.2 |
| NCBI Gene ID | 253314 ncbi.nlm.nih.gov/gene/253314 |
| Ensembl ID | ENSG00000164172 |
| UniProt ID | Q6P5X7 |
| OMIM ID | 617538 |
| HGNC ID | 32913 |
| Aliases | EIF4E1B, FLJ36980, MGC138290 |
Description
EIF4E1B (Eukaryotic Translation Initiation Factor 4E Family Member 1B) is a protein-coding gene belonging to the EIF4E family. The encoded protein binds the 5' cap of mRNA and is involved in cap-dependent translation initiation. It is predominantly expressed in testis and may play a role in germ cell development. EIF4E1B has been implicated in certain cancers, including breast and lung cancer, through altered expression and potential oncogenic activity.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast Cancer | Overexpression of EIF4E1B may promote translation of oncogenic mRNAs, contributing to tumorigenesis. | COSMIC, literature |
| Lung Cancer | Altered EIF4E1B expression observed in lung adenocarcinoma; potential role in cell proliferation. | COSMIC, literature |
| Testicular Germ Cell Tumors | EIF4E1B expression in testis suggests possible involvement in germ cell tumor development. | NCBI, literature |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Brain | 2.1 | Low |
| Lung | 1.8 | Low |
| Breast | 1.5 | Low |
| Liver | 0.9 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 (breast cancer) | 3.2 | Moderate expression |
| A549 (lung cancer) | 2.8 | Moderate expression |
| HEK293 (embryonic kidney) | 1.5 | Low expression |
| NTERA-2 (testicular germ cell) | 8.9 | High expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.101A>G (p.Tyr34Cys) | Missense | <0.01% | Unknown; predicted benign by in silico tools |
| c.205C>T (p.Arg69Trp) | Missense | <0.01% | Unknown; predicted possibly damaging |
| c.312_313insA (p.Thr105fs) | Frameshift | <0.01% | Loss of function; likely pathogenic |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations (e.g., p.Thr105fs) are predicted to cause loss of function by truncating the protein.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in EIF4E1B.
Dominant Negative (DN)
No evidence for dominant-negative effects in EIF4E1B.
View complete mutation data：
Gene Ontology (GO)
| • translation initiation factor activity (GO:0003743) | • RNA 7-methylguanosine cap binding (GO:0000340) |
| • translational initiation (GO:0006413) | • cytoplasm (GO:0005737) |
Pathways
• hsa03013: RNA transport
• hsa04150: mTOR signaling pathway (indirect via eIF4E family)
Protein Summary
EIF4E1B encodes a 25.5 kDa protein (217 amino acids) that belongs to the eIF4E family. It contains a conserved cap-binding domain that recognizes the 5' 7-methylguanosine cap of mRNAs, facilitating ribosome recruitment and translation initiation. Unlike the canonical eIF4E, EIF4E1B is primarily expressed in testis and may have specialized roles in germ cell translation. Structural studies show it shares the typical eIF4E fold with a curved β-sheet and α-helices. The protein interacts with eIF4G and other initiation factors, though its affinity for the cap may be lower than that of EIF4E1.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| EIF4E1B Knockout HEK293 Cell Line | EDJ-KQ791 | Human | 253314 | Details Get a Quote |
| EIF4E1B Knockout HeLa Cell Line | EDJ-KQ59241 | Human | 253314 | Details Get a Quote |
| EIF4E1B Knockout A-549 Cell Line | EDJ-KQ67709 | Human | 253314 | Details Get a Quote |
| EIF4E1B Knockout HCT 116 Cell Line | EDJ-KQ76091 | Human | 253314 | Details Get a Quote |
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