EID2B
EP300 Interacting Inhibitor of Differentiation 2B
Gene Information Card
| Symbol | EID2B |
|---|---|
| Full Name | EP300 Interacting Inhibitor of Differentiation 2B |
| Gene Type | protein-coding |
| Chromosomal Location | 19q13.2 |
| NCBI Gene ID | 100129924 ncbi.nlm.nih.gov/gene/100129924 |
| Ensembl ID | ENSG00000205571 |
| UniProt ID | Q8N6I1 |
| OMIM ID | 617631 |
| HGNC ID | 33810 |
| Aliases | EID-2B, FLJ39653 |
Description
EID2B encodes a protein that interacts with EP300, a histone acetyltransferase involved in transcriptional coactivation. The EID2B protein acts as an inhibitor of EP300-mediated transcriptional activation and may play a role in regulating cell differentiation and proliferation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease associations reported | Not established | No evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 5.2 | Low |
| Brain | 2.1 | Low |
| Lung | 1.8 | Low |
| Liver | 1.5 | Low |
| Kidney | 1.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 3.4 | Low expression |
| HeLa | 2.9 | Low expression |
| K562 | 1.7 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic variants reported | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
Not characterized
Gain of Function (GOF)
Not characterized
Dominant Negative (DN)
Not characterized
View complete mutation data：
Gene Ontology (GO)
| • transcription corepressor activity (GO:0003714) | • nucleus (GO:0005634) |
| • negative regulation of transcription by RNA polymerase II (GO:0000122) |
Pathways
• Not annotated in major pathway databases
Protein Summary
EID2B is a 200-amino acid protein that contains an EID (EP300-interacting inhibitor of differentiation) domain. It localizes to the nucleus and represses EP300-dependent transcription, potentially modulating cell cycle and differentiation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| EID2B Knockout HEK293 Cell Line | EDJ-KQ8881 | Human | 126272 | Details Get a Quote |
| EID2B Knockout HeLa Cell Line | EDJ-KQ33973 | Human | 126272 | Details Get a Quote |
| EID2B Knockout A-549 Cell Line | EDJ-KQ35205 | Human | 126272 | Details Get a Quote |
| EID2B Knockout HCT 116 Cell Line | EDJ-KQ35206 | Human | 126272 | Details Get a Quote |
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