EID2: EP300 Interacting Inhibitor of Differentiation 2
A transcriptional regulator involved in cell differentiation and potential tumor suppression.
Gene Information Card
| Symbol | EID2 |
|---|---|
| Full Name | EP300 interacting inhibitor of differentiation 2 |
| Gene Type | protein-coding |
| Chromosomal Location | 19q13.2 |
| NCBI Gene ID | 163126 ncbi.nlm.nih.gov/gene/163126 |
| Ensembl ID | ENSG00000160180 |
| UniProt ID | Q8N6I1 |
| OMIM ID | 617571 |
| HGNC ID | 28317 |
| Aliases | CREBBP/EP300 inhibitor 2, EID-2, C15orf21 |
Description
EID2 (EP300 interacting inhibitor of differentiation 2) encodes a protein that interacts with the transcriptional coactivators EP300 and CREBBP, repressing their acetyltransferase activity and inhibiting differentiation in certain cell types. It is involved in cell cycle regulation and may function as a tumor suppressor.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | EID2 downregulation may promote proliferation via EP300 dysregulation; loss of EID2 expression correlates with poor prognosis. | PMID: 23431173 |
| Colorectal cancer | EID2 promoter hypermethylation leads to silencing; re-expression reduces tumor growth in vitro. | PMID: 25670082 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.3 | Medium |
| Brain | 8.7 | Low |
| Lung | 6.1 | Low |
| Liver | 4.5 | Low |
| Kidney | 5.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 10.1 | Embryonic kidney; moderate expression |
| HeLa | 7.8 | Cervical carcinoma; lower than normal |
| MCF7 | 3.2 | Breast cancer; reduced expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | Missense | <0.01% | Likely loss of start codon; predicted loss of function |
| c.325C>T (p.Arg109Trp) | Missense | <0.01% | Unknown significance; not in ClinVar |
Mutation functional classification
Loss of Function (LOF)
Loss-of-function mutations (e.g., start codon loss) are predicted to reduce EID2 protein levels, potentially impairing its repressive role on EP300 and promoting cell proliferation.
Gain of Function (GOF)
No gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
Pathways
• EP300/CREBBP-mediated transcription
• Notch signaling (via interaction with EP300)
Protein Summary
EID2 is a 200-amino-acid nuclear protein that binds to the CH1 domain of EP300 and CREBBP, inhibiting their histone acetyltransferase activity. It acts as a transcriptional repressor, blocking differentiation in myoblasts and other cell types. The protein contains a conserved EID homology domain and is expressed in multiple tissues, with highest levels in testis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| EID2B Knockout HEK293 Cell Line | EDJ-KQ8881 | Human | 126272 | Details Get a Quote |
| EID2 Knockout HEK293 Cell Line | EDJ-KQ13267 | Human | 163126 | Details Get a Quote |
| EID2B Knockout HeLa Cell Line | EDJ-KQ33973 | Human | 126272 | Details Get a Quote |
| EID2B Knockout A-549 Cell Line | EDJ-KQ35205 | Human | 126272 | Details Get a Quote |
| EID2B Knockout HCT 116 Cell Line | EDJ-KQ35206 | Human | 126272 | Details Get a Quote |
| EID2 Knockout HCT 116 Cell Line | EDJ-KQ41447 | Human | 163126 | Details Get a Quote |
| EID2 Knockout A-549 Cell Line | EDJ-KQ42672 | Human | 163126 | Details Get a Quote |
| EID2 Knockout HeLa Cell Line | EDJ-KQ42674 | Human | 163126 | Details Get a Quote |
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