EDC3 Gene - Enhancer of mRNA Decapping 3 | Function, Mutations & Disease

EDC3 encodes a protein that functions as an enhancer of mRNA decapping, a critical step in the 5'-to-3' mRNA decay pathway. The protein localizes to cytoplasmic processing bodies (P-bodies) and interacts with the decapping enzyme DCP2 and other decapping cofactors. EDC3 contains an LSm domain and a YjeF-N domain, which are involved in RNA binding and protein-protein interactions. It plays a role in post-transcriptional gene regulation by promoting the removal of the 5' cap from mRNAs, thereby facilitating their degradation.

Tissue Expression

Cell Line Expression

Hotspot Mutations

Mutation functional classification

• mRNA decay by 5'-to-3' exoribonuclease

• Processing of capped intron-containing pre-mRNA

EDC3 is a 508-amino acid protein with a molecular weight of approximately 57 kDa. It contains an N-terminal LSm domain (residues 1-70) that mediates RNA binding and interaction with the decapping complex, and a C-terminal YjeF-N domain (residues 200-400) of unknown function but conserved in bacteria and eukaryotes. The protein is predominantly cytoplasmic and localizes to P-bodies, where it enhances the activity of DCP2. EDC3 also interacts with other decapping factors such as DCP1A, DDX6, and PATL1. Post-translational modifications include phosphorylation, which may regulate its localization and activity.