E2F5
E2F Transcription Factor 5
Gene Information Card
| Symbol | E2F5 |
|---|---|
| Full Name | E2F transcription factor 5 |
| Gene Type | protein-coding |
| Chromosomal Location | 8q21.2 |
| NCBI Gene ID | 1875 ncbi.nlm.nih.gov/gene/1875 |
| Ensembl ID | ENSG00000133740 |
| UniProt ID | Q15329 |
| OMIM ID | 600967 |
| HGNC ID | 3118 |
| Aliases | E2F-5 |
Description
E2F5 is a member of the E2F family of transcription factors that regulate cell cycle progression and DNA synthesis. It forms heterodimers with DP proteins and binds to E2F consensus sites in target gene promoters. E2F5 is primarily involved in repressing transcription during quiescence and is implicated in development and cancer.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Bladder cancer | Overexpression of E2F5 promotes cell proliferation and tumorigenesis | PMID: 15696293 |
| Prostate cancer | E2F5 upregulation correlates with poor prognosis and androgen independence | PMID: 17975020 |
| Breast cancer | E2F5 amplification and overexpression contribute to oncogenic signaling | PMID: 12460918 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Lymph node | 8.3 | Low |
| Brain | 6.1 | Low |
| Lung | 5.4 | Low |
| Liver | 4.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 15.2 | Embryonic kidney |
| HeLa | 12.8 | Cervical carcinoma |
| MCF7 | 10.5 | Breast cancer |
| A549 | 9.1 | Lung carcinoma |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | <0.1% | Unknown |
| c.100C>T | missense | <0.1% | Unknown |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in COSMIC or ClinVar.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • DNA-binding transcription factor activity | • RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| • cell cycle | • G1/S transition of mitotic cell cycle |
| • nucleus |
Pathways
• Cell Cycle
• G1/S Checkpoint
• E2F transcription factor network
Protein Summary
E2F5 is a 346-amino acid protein containing a DNA-binding domain, a dimerization domain, and a transactivation domain. It preferentially binds to the E2F consensus site TTTCGCGC and represses transcription when associated with pocket proteins. E2F5 is highly expressed in testis and certain cancers, where it may drive proliferation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| E2F5 Knockout HEK293 Cell Line | EDJ-KQ375 | Human | 1875 | Details Get a Quote |
| E2F5 Knockout A-549 Cell Line | EDJ-KQ18578 | Human | 1875 | Details Get a Quote |
| E2F5 Knockout HCT 116 Cell Line | EDJ-KQ18579 | Human | 1875 | Details Get a Quote |
| E2F5 Knockout HeLa Cell Line | EDJ-KQ18580 | Human | 1875 | Details Get a Quote |
