DYNLL2
Dynein Light Chain 2, Cytoplasmic
Gene Information Card
| Symbol | DYNLL2 |
|---|---|
| Full Name | dynein light chain 2, cytoplasmic |
| Gene Type | protein-coding |
| Chromosomal Location | 17q22 |
| NCBI Gene ID | 140735 ncbi.nlm.nih.gov/gene/140735 |
| Ensembl ID | ENSG00000108821 |
| UniProt ID | Q96FJ2 |
| OMIM ID | 608942 |
| HGNC ID | 15477 |
| Aliases | DLC2, DNCL2B, DLC8B, DYNLL2 |
Description
DYNLL2 (dynein light chain 2, cytoplasmic) encodes a light chain component of the cytoplasmic dynein complex. This protein is involved in microtubule-based retrograde transport, binding to cargo and regulating dynein motor activity. DYNLL2 also participates in apoptosis through interaction with BCL2 family members and modulates transcription factor localization.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | DYNLL2 overexpression correlates with poor prognosis; may promote cell migration via dynein-mediated transport | COSMIC, ClinVar |
| Colorectal cancer | Altered expression linked to tumor progression; potential role in Wnt signaling modulation | COSMIC |
| Neurodegenerative disorders | Impaired axonal transport due to DYNLL2 dysfunction may contribute to motor neuron degeneration | NCBI Gene, UniProt |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 15.2 | Medium |
| Heart | 12.8 | Medium |
| Liver | 8.5 | Low |
| Kidney | 11.3 | Medium |
| Testis | 20.1 | High |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 18.5 | High expression |
| HeLa | 14.2 | Medium expression |
| HepG2 | 9.8 | Low expression |
| SH-SY5Y | 16.7 | High expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.94G>A (p.Glu32Lys) | missense | 0.01% | Unknown functional impact; rare population variant |
| c.205C>T (p.Arg69Trp) | missense | 0.005% | Reported in COSMIC; potential loss of interaction with cargo |
| c.301A>G (p.Ile101Val) | missense | 0.02% | Benign; no known disease association |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
Pathways
• KEGG: hsa04144 - Endocytosis
• Reactome: R-HSA-983168 - Antigen processing: Ubiquitination & Proteasome degradation
• Reactome: R-HSA-5620912 - Anchoring of the basal body to the plasma membrane
Protein Summary
DYNLL2 encodes a 102-amino-acid light chain (12 kDa) that forms homodimers and binds to the dynein intermediate chain. It is highly conserved and expressed in multiple tissues. The protein shuttles between cytoplasm and nucleus, and its dimerization is essential for cargo binding. Post-translational modifications include phosphorylation at Ser88, which may regulate dynein complex assembly.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| DYNLL2 Knockout HEK293 Cell Line | EDJ-KQ3771 | Human | 140735 | Details Get a Quote |
| DYNLL2 Knockout A-549 Cell Line | EDJ-KQ25859 | Human | 140735 | Details Get a Quote |
| DYNLL2 Knockout HCT 116 Cell Line | EDJ-KQ25860 | Human | 140735 | Details Get a Quote |
| DYNLL2 Knockout HeLa Cell Line | EDJ-KQ25861 | Human | 140735 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
