DUSP22
Dual Specificity Phosphatase 22
Gene Information Card
| Symbol | DUSP22 |
|---|---|
| Full Name | Dual Specificity Phosphatase 22 |
| Gene Type | Protein coding |
| Chromosomal Location | 6p25.3 |
| NCBI Gene ID | 56940 ncbi.nlm.nih.gov/gene/56940 |
| Ensembl ID | ENSG00000112658 |
| UniProt ID | Q9NRW4 |
| OMIM ID | 616637 |
| HGNC ID | 16077 |
| Aliases | JSP1, MKP-X, LMWDSP2, VHX |
Description
DUSP22 (dual specificity phosphatase 22) encodes a member of the dual specificity protein phosphatase subfamily. This phosphatase dephosphorylates phosphotyrosine and phosphoserine/threonine residues, negatively regulating MAP kinase signaling. It is involved in cell proliferation, differentiation, and apoptosis. DUSP22 is frequently rearranged in anaplastic large cell lymphoma and other cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Anaplastic large cell lymphoma (ALCL) | DUSP22 rearrangements (e.g., with DUSP22-IRF4 locus) lead to aberrant phosphatase expression and altered MAPK signaling, promoting lymphomagenesis. | PMID: 26980727; COSMIC |
| Cutaneous T-cell lymphoma | DUSP22 deletions or rearrangements contribute to oncogenic signaling. | PMID: 28453780; ClinVar |
| Breast cancer | DUSP22 overexpression correlates with poor prognosis; may modulate ERK pathway. | PMID: 23382210; NCBI Gene |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.3 | Medium |
| Lymph node | 8.7 | Medium |
| Spleen | 7.1 | Medium |
| Brain | 2.5 | Low |
| Liver | 1.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 9.5 | Moderate expression |
| K562 | 6.8 | Moderate expression |
| HeLa | 4.2 | Low expression |
| Jurkat | 11.0 | High expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | Missense | <0.1% | Loss of start codon; likely loss of function |
| c.374C>T (p.Thr125Met) | Missense | 0.2% | Unknown significance; reported in lymphoma |
| DUSP22-IRF4 rearrangement | Structural variant | ~30% in ALCL | Fusion leads to overexpression of DUSP22 |
Mutation functional classification
Loss of Function (LOF)
Nonsense or frameshift mutations that truncate the phosphatase domain, reducing MAPK dephosphorylation.
Gain of Function (GOF)
Rearrangements (e.g., DUSP22-IRF4) that increase DUSP22 expression, potentially altering signaling.
Dominant Negative (DN)
Not well characterized; some missense variants may interfere with substrate binding.
View complete mutation data：
Gene Ontology (GO)
| • protein tyrosine phosphatase activity | • MAP kinase phosphatase activity |
| • protein serine/threonine phosphatase activity | • negative regulation of MAPK cascade |
| • dephosphorylation | • cytoplasm |
| • nucleus |
Pathways
• MAPK signaling pathway (Reactome: R-HSA-5673001)
• DUSP22-mediated dephosphorylation of ERK
Protein Summary
DUSP22 is a 184-amino acid dual specificity phosphatase that preferentially dephosphorylates ERK2 and p38 MAP kinases. It contains a conserved catalytic domain and a short N-terminal extension. The protein localizes to both cytoplasm and nucleus. DUSP22 plays a role in immune cell function and is implicated in T-cell lymphomas.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| DUSP22 Knockout HEK293 Cell Line | EDJ-KQ13225 | Human | 56940 | Details Get a Quote |
| DUSP22 Knockout HeLa Cell Line | EDJ-KQ41377 | Human | 56940 | Details Get a Quote |
| DUSP22 Knockout A-549 Cell Line | EDJ-KQ42603 | Human | 56940 | Details Get a Quote |
| DUSP22 Knockout HCT 116 Cell Line | EDJ-KQ42604 | Human | 56940 | Details Get a Quote |
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