DUSP21
Dual Specificity Phosphatase 21
Gene Information Card
| Symbol | DUSP21 |
|---|---|
| Full Name | Dual Specificity Phosphatase 21 |
| Gene Type | Protein coding |
| Chromosomal Location | 1p36.22 |
| NCBI Gene ID | 401458 ncbi.nlm.nih.gov/gene/401458 |
| Ensembl ID | ENSG00000185499 |
| UniProt ID | Q5D1E8 |
| OMIM ID | 617060 |
| HGNC ID | 16149 |
| Aliases | MKP-21, DUSP21 |
Description
DUSP21 (dual specificity phosphatase 21) is a protein-coding gene located on chromosome 1p36.22. It encodes a member of the dual specificity phosphatase (DUSP) family, which dephosphorylates both phosphotyrosine and phosphoserine/threonine residues. DUSP21 is known to inactivate mitogen-activated protein kinases (MAPKs) such as ERK and p38, thereby regulating cell proliferation, differentiation, and stress responses. Expression is enriched in testis and certain cancer cell lines.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (general) | DUSP21 may modulate MAPK signaling, influencing tumor growth and survival | Limited; expression changes observed in some cancers (COSMIC) |
| Male infertility | Potential role in spermatogenesis via MAPK regulation | Hypothetical based on testis expression |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Prostate | 3.2 | Low |
| Thyroid | 2.1 | Low |
| Adrenal gland | 1.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 8.4 | Moderate expression |
| HeLa | 5.1 | Low expression |
| K562 | 3.7 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | Missense | <0.01% | Potential loss of start codon |
| c.214C>T (p.Arg72Trp) | Missense | <0.01% | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant negative effects.
View complete mutation data：
Gene Ontology (GO)
| • protein tyrosine phosphatase activity | • MAP kinase phosphatase activity |
| • dephosphorylation | • negative regulation of MAPK cascade |
| • cytoplasm |
Pathways
• MAPK signaling pathway
• Dual specificity phosphatase pathway
Protein Summary
DUSP21 encodes a 176-amino acid dual specificity phosphatase with a conserved catalytic domain. It specifically dephosphorylates phosphothreonine and phosphotyrosine residues on MAP kinases, particularly ERK and p38. The protein is predominantly cytoplasmic and is implicated in negative regulation of cell growth and stress responses.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| DUSP21 Knockout HEK293 Cell Line | EDJ-KQ13224 | Human | 63904 | Details Get a Quote |
| DUSP21 Knockout HeLa Cell Line | EDJ-KQ56993 | Human | 63904 | Details Get a Quote |
| DUSP21 Knockout A-549 Cell Line | EDJ-KQ65497 | Human | 63904 | Details Get a Quote |
| DUSP21 Knockout HCT 116 Cell Line | EDJ-KQ73934 | Human | 63904 | Details Get a Quote |
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