DUSP18
Dual Specificity Phosphatase 18
Gene Information Card
| Symbol | DUSP18 |
|---|---|
| Full Name | Dual Specificity Phosphatase 18 |
| Gene Type | Protein coding |
| Chromosomal Location | 22q12.1 |
| NCBI Gene ID | 150290 ncbi.nlm.nih.gov/gene/150290 |
| Ensembl ID | ENSG00000100290 |
| UniProt ID | Q8N6M0 |
| OMIM ID | 611437 |
| HGNC ID | 28510 |
| Aliases | DUSP20, LMWDSP3, DSP18 |
Description
DUSP18 encodes a member of the dual specificity phosphatase (DUSP) family, which dephosphorylates phosphotyrosine and phosphoserine/threonine residues. It is a low molecular weight phosphatase that negatively regulates MAPK signaling, particularly JNK and p38 pathways. DUSP18 is localized to mitochondria and may play roles in apoptosis and cellular stress responses.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (general) | Altered DUSP18 expression may dysregulate MAPK signaling, promoting tumorigenesis | COSMIC, literature |
| Neurodegenerative disorders | Impaired JNK/p38 regulation via DUSP18 may contribute to neuronal cell death | NCBI Gene, literature |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Brain | 8.2 | Low |
| Liver | 5.1 | Low |
| Kidney | 4.3 | Low |
| Heart | 3.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 10.1 | Moderate expression |
| HeLa | 7.8 | Low expression |
| K562 | 6.5 | Low expression |
| SH-SY5Y | 9.3 | Moderate expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.157C>T (p.Arg53Trp) | Missense | <0.01% | Unknown functional impact |
| c.244G>A (p.Gly82Ser) | Missense | <0.01% | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in DUSP18.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in DUSP18.
Dominant Negative (DN)
No dominant-negative mutations described for DUSP18.
View complete mutation data：
Gene Ontology (GO)
Pathways
• MAPK signaling pathway (negative regulation)
• JNK cascade
• p38 MAPK cascade
Protein Summary
DUSP18 is a 188-amino acid dual specificity phosphatase with a molecular weight of approximately 21 kDa. It contains a conserved catalytic domain characteristic of the DUSP family. The protein localizes to mitochondria and dephosphorylates MAP kinases, particularly JNK and p38, thereby attenuating stress-activated signaling. DUSP18 is expressed in testis, brain, and other tissues, and its dysregulation has been implicated in cancer and neurodegenerative conditions.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| DUSP18 Knockout HEK293 Cell Line | EDJ-KQ52038 | Human | 150290 | Details Get a Quote |
| DUSP18 Knockout HeLa Cell Line | EDJ-KQ58655 | Human | 150290 | Details Get a Quote |
| DUSP18 Knockout A-549 Cell Line | EDJ-KQ67136 | Human | 150290 | Details Get a Quote |
| DUSP18 Knockout HCT 116 Cell Line | EDJ-KQ75542 | Human | 150290 | Details Get a Quote |
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