DUSP13B Gene - Dual Specificity Phosphatase 13B
A member of the dual-specificity phosphatase family involved in MAPK signaling regulation.
Gene Information Card
| Symbol | DUSP13B |
|---|---|
| Full Name | Dual specificity phosphatase 13B |
| Gene Type | protein-coding |
| Chromosomal Location | 10q22.2 |
| NCBI Gene ID | 51207 ncbi.nlm.nih.gov/gene/51207 |
| Ensembl ID | ENSG00000120053 |
| UniProt ID | Q9BQ90 |
| OMIM ID | 610036 |
| HGNC ID | 30622 |
| Aliases | MDSP, SKRP4, TMDP, DUSP13 |
Description
DUSP13B (dual specificity phosphatase 13B) is a protein-coding gene that encodes a member of the dual-specificity phosphatase (DUSP) family. These phosphatases inactivate mitogen-activated protein kinases (MAPKs) by dephosphorylating both phosphoserine/threonine and phosphotyrosine residues. DUSP13B specifically dephosphorylates and inactivates MAPK8/JNK1 and MAPK14/p38, thereby negatively regulating stress-activated MAPK signaling pathways. The gene is located on chromosome 10q22.2 and is expressed in multiple tissues, with highest levels in testis and skeletal muscle.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Prostate cancer | Altered expression may affect MAPK signaling, promoting cell proliferation | COSMIC mutation data; limited clinical evidence |
| Colorectal cancer | Potential dysregulation of JNK/p38 pathways | COSMIC mutation data; no direct mechanism established |
| Breast cancer | Possible role in tumor suppression via MAPK inhibition | Low-frequency mutations in COSMIC; functional studies needed |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Skeletal muscle | 8.3 | Low |
| Heart | 5.1 | Low |
| Liver | 2.0 | Not detected |
| Brain | 1.5 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 3.2 | Low expression |
| HEK293 | 2.8 | Low expression |
| K562 | 1.1 | Not detected |
| MCF7 | 4.0 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.337C>T (p.Arg113Trp) | missense | 0.02% | Unknown; predicted damaging by SIFT |
| c.454G>A (p.Glu152Lys) | missense | 0.01% | Unknown; predicted benign |
| c.123_124insA | frameshift | <0.01% | Loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations (e.g., c.123_124insA) likely result in truncated protein and loss of phosphatase activity.
Gain of Function (GOF)
No gain-of-function mutations reported in COSMIC or ClinVar.
Dominant Negative (DN)
No dominant-negative mutations described.
View complete mutation data：
Gene Ontology (GO)
Pathways
• MAPK signaling pathway (Reactome: R-HSA-5687128)
• JNK cascade (Reactome: R-HSA-450321)
• p38 MAPK signaling (Reactome: R-HSA-450294)
Protein Summary
DUSP13B encodes a 198-amino acid protein with a dual-specificity phosphatase domain. It localizes to both cytoplasm and nucleus and specifically dephosphorylates JNK1 and p38 MAP kinases, leading to their inactivation. The protein plays a role in negatively regulating stress responses and may function as a tumor suppressor in certain cancers. Expression is enriched in testis and skeletal muscle.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| DUSP13B Knockout HEK293 Cell Line | EDJ-KQ51294 | Human | 51207 | Details Get a Quote |
| DUSP13B Knockout HeLa Cell Line | EDJ-KQ56250 | Human | 51207 | Details Get a Quote |
| DUSP13B Knockout A-549 Cell Line | EDJ-KQ64739 | Human | 51207 | Details Get a Quote |
| DUSP13B Knockout HCT 116 Cell Line | EDJ-KQ73184 | Human | 51207 | Details Get a Quote |
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