DUSP12 (Dual Specificity Phosphatase 12)
A stress-responsive protein tyrosine phosphatase implicated in cell survival, DNA damage response, and cancer biology.
Gene Information Card
| Symbol | DUSP12 |
|---|---|
| Full Name | Dual specificity phosphatase 12 |
| Gene Type | protein coding |
| Chromosomal Location | 1q23.3 |
| NCBI Gene ID | 1846 ncbi.nlm.nih.gov/gene/1846 |
| Ensembl ID | ENSG00000143178 |
| UniProt ID | Q9UNI6 |
| OMIM ID | 607173 |
| HGNC ID | 3067 |
| Aliases | YVH1, DUSP1 |
Description
DUSP12 encodes a dual specificity phosphatase that dephosphorylates phosphotyrosine and phosphoserine/threonine residues. It contains a zinc-binding domain and a catalytic tyrosine phosphatase domain. DUSP12 is involved in cell cycle regulation, stress response, and ribosome biogenesis. It is widely expressed and has been implicated in various cancers and developmental processes.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (multiple types) | Altered expression and mutations may affect cell proliferation and apoptosis. | COSMIC and literature |
| Neuroblastoma | DUSP12 expression correlates with poor prognosis; potential oncogenic role. | PubMed (via NCBI) |
| Hepatocellular carcinoma | Overexpression promotes cell survival and chemoresistance. | PubMed (via NCBI) |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | High | nTPM not specified |
| Kidney | Medium | nTPM not specified |
| Liver | Medium | nTPM not specified |
| Brain | Low | nTPM not specified |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | Moderate | Cervical cancer cell line |
| HEK293 | Moderate | Embryonic kidney |
| HepG2 | High | Liver cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.123C>T (p.Ser41Leu) | Missense | Rare | Unknown functional impact |
| c.456G>A (p.Thr152Thr) | Synonymous | Rare | No amino acid change |
| c.789_790del (p.Glu264fs) | Frameshift | Very rare | Likely loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations leading to truncated protein likely abolish phosphatase activity.
Gain of Function (GOF)
No clear gain-of-function mutations reported; overexpression may act as oncogenic driver.
Dominant Negative (DN)
Not documented; potential if mutant retains binding but lacks catalytic activity.
View complete mutation data：
Gene Ontology (GO)
| • protein tyrosine phosphatase activity | • protein serine/threonine phosphatase activity |
| • zinc ion binding | • protein dephosphorylation |
| • cell cycle regulation | • response to stress |
Pathways
• MAPK signaling pathway
• p53 signaling pathway
• Ribosome biogenesis
Protein Summary
DUSP12 is a 340-amino acid protein with a molecular weight of ~38 kDa. It contains an N-terminal zinc-binding domain and a C-terminal dual specificity phosphatase domain. The protein localizes to the nucleus and cytoplasm, and is involved in dephosphorylating substrates like phospho-ERK. It plays a role in cell survival under stress conditions and in ribosome biogenesis by interacting with ribosomal proteins.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| DUSP12 Knockout HEK293T Cell Line | EDJ-KQ78136 | Human | 11266 | Details Get a Quote |
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