DRAXIN
Dorsal Inhibitory Axon Guidance Protein
Gene Information Card
| Symbol | DRAXIN |
|---|---|
| Full Name | Dorsal Inhibitory Axon Guidance Protein |
| Gene Type | Protein coding |
| Chromosomal Location | 1p36.22 |
| NCBI Gene ID | 374864 ncbi.nlm.nih.gov/gene/374864 |
| Ensembl ID | ENSG00000162493 |
| UniProt ID | Q8NBI3 |
| OMIM ID | 609303 |
| HGNC ID | 24878 |
| Aliases | C1orf187, DRAX, FLJ37953 |
Description
DRAXIN (dorsal inhibitory axon guidance protein) is a secreted protein that functions as a chemorepellent during neural development, guiding axons away from the dorsal spinal cord. It is also implicated in cancer cell migration and proliferation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal cancer | Overexpression promotes tumor growth and metastasis | PMID: 25944712 |
| Breast cancer | Upregulation associated with poor prognosis | PMID: 27397505 |
| Neurodevelopmental disorders | Altered expression may disrupt axon guidance | PMID: 19640509 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 0.8 | Low |
| Spinal cord | 1.2 | Low |
| Colon | 3.5 | Medium |
| Breast | 2.1 | Low |
| Testis | 0.5 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HCT116 (colon cancer) | 4.2 | Moderate expression |
| MCF7 (breast cancer) | 2.8 | Low expression |
| SH-SY5Y (neuroblastoma) | 1.5 | Low expression |
| HEK293 (embryonic kidney) | 0.3 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.287G>A (p.Arg96Gln) | Missense | 0.01% | Unknown functional impact |
| c.451C>T (p.Pro151Ser) | Missense | 0.005% | Predicted benign |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported.
Gain of Function (GOF)
Overexpression in cancers suggests potential gain-of-function role.
Dominant Negative (DN)
Not described.
View complete mutation data：
Gene Ontology (GO)
| • axon guidance | • chemorepulsion |
| • extracellular region | • signal transduction |
Pathways
• Axon guidance (Reactome: R-HSA-422475)
Protein Summary
DRAXIN is a 349-amino acid secreted protein containing a signal peptide and a cysteine-rich domain. It binds to the DCC receptor to mediate repulsive axon guidance. In cancer, DRAXIN overexpression enhances cell migration and invasion.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| DRAXIN Knockout HEK293 Cell Line | EDJ-KQ13214 | Human | 374946 | Details Get a Quote |
| DRAXIN Knockout HeLa Cell Line | EDJ-KQ59910 | Human | 374946 | Details Get a Quote |
| DRAXIN Knockout A-549 Cell Line | EDJ-KQ68372 | Human | 374946 | Details Get a Quote |
| DRAXIN Knockout HCT 116 Cell Line | EDJ-KQ76750 | Human | 374946 | Details Get a Quote |
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