DOCK10
Dedicator of cytokinesis 10
Gene Information Card
| Symbol | DOCK10 |
|---|---|
| Full Name | Dedicator of cytokinesis 10 |
| Gene Type | Protein coding |
| Chromosomal Location | 2q36.2 |
| NCBI Gene ID | 55619 ncbi.nlm.nih.gov/gene/55619 |
| Ensembl ID | ENSG00000115970 |
| UniProt ID | Q96BY6 |
| OMIM ID | 611417 |
| HGNC ID | 23479 |
| Aliases | ZIZ3, DOCK10, Nbla10300, FLJ10656 |
Description
DOCK10 (dedicator of cytokinesis 10) is a protein-coding gene that encodes a member of the DOCK family of guanine nucleotide exchange factors (GEFs). The protein specifically activates the small GTPase Rac1, playing a key role in cytoskeletal rearrangements, cell migration, and immune cell signaling. DOCK10 is involved in B-cell development and function, and its dysregulation has been implicated in certain cancers and immune disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Chronic lymphocytic leukemia (CLL) | DOCK10 mutations may alter Rac1 signaling, affecting B-cell proliferation and survival. | COSMIC, ClinVar |
| Lung adenocarcinoma | Somatic mutations in DOCK10 have been identified, potentially contributing to tumor progression. | COSMIC |
| Melanoma | Recurrent mutations in DOCK10 reported, possibly influencing cell migration and invasion. | COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lymph node | 12.5 | Medium |
| Spleen | 10.8 | Medium |
| Bone marrow | 8.2 | Medium |
| Lung | 4.1 | Low |
| Brain | 1.3 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| K-562 (leukemia) | 15.2 | High expression |
| HeLa (cervical) | 6.8 | Medium expression |
| A549 (lung) | 4.5 | Low expression |
| MCF7 (breast) | 3.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| p.Arg1098* | Nonsense | <0.1% | Premature truncation, likely loss of function |
| p.Glu1125Lys | Missense | <0.1% | Unknown effect; reported in CLL |
| p.Val1230Ile | Missense | <0.1% | Unknown effect; reported in melanoma |
Mutation functional classification
Loss of Function (LOF)
Nonsense mutations (e.g., p.Arg1098*) are predicted to cause loss of function by truncating the protein.
Gain of Function (GOF)
No gain-of-function mutations have been conclusively reported for DOCK10.
Dominant Negative (DN)
No dominant-negative mutations have been characterized for DOCK10.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Rac1 signaling pathway
• Regulation of actin cytoskeleton
• Fc gamma R-mediated phagocytosis
• B cell receptor signaling pathway
Protein Summary
DOCK10 is a 219-kDa protein that functions as a guanine nucleotide exchange factor (GEF) for Rac1, a small GTPase involved in cytoskeletal dynamics and cell migration. The protein contains a DHR-2 (DOCK homology region 2) domain responsible for catalytic activity and a DHR-1 domain that binds phospholipids for membrane targeting. DOCK10 is predominantly expressed in lymphoid tissues and is critical for B-cell receptor signaling and immune synapse formation. Alternative splicing generates multiple isoforms.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| DOCK10 Knockout HEK293 Cell Line | EDJ-KQ13195 | Human | 55619 | Details Get a Quote |
| DOCK10 Knockout A-549 Cell Line | EDJ-KQ42563 | Human | 55619 | Details Get a Quote |
| DOCK10 Knockout HeLa Cell Line | EDJ-KQ42564 | Human | 55619 | Details Get a Quote |
| DOCK10 Knockout HCT 116 Cell Line | EDJ-KQ73557 | Human | 55619 | Details Get a Quote |
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