DMTF1 (Cyclin D Binding Myb-Like Transcription Factor 1)
A tumor suppressor gene encoding a transcription factor that regulates cell cycle and apoptosis.
Gene Information Card
| Symbol | DMTF1 |
|---|---|
| Full Name | Cyclin D Binding Myb-Like Transcription Factor 1 |
| Gene Type | protein-coding |
| Chromosomal Location | 7q21.12 |
| NCBI Gene ID | 9988 ncbi.nlm.nih.gov/gene/9988 |
| Ensembl ID | ENSG00000106333 |
| UniProt ID | Q9Y222 |
| OMIM ID | 607482 |
| HGNC ID | 2928 |
| Aliases | DMP1, DMTF, hDMP1 |
Description
DMTF1 (Cyclin D Binding Myb-Like Transcription Factor 1) is a tumor suppressor gene located on chromosome 7q21.12. It encodes a transcription factor that binds to cyclin D and regulates the expression of genes involved in cell cycle progression, apoptosis, and differentiation. DMTF1 is frequently inactivated in various cancers, contributing to uncontrolled cell proliferation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Lung Cancer | Loss of DMTF1 expression leads to increased cell proliferation and reduced apoptosis. | PMID: 14562041 |
| Breast Cancer | DMTF1 inactivation via promoter methylation or deletion promotes tumorigenesis. | PMID: 17952127 |
| Colorectal Cancer | Reduced DMTF1 expression correlates with poor prognosis and metastasis. | PMID: 21750550 |
| Leukemia | DMTF1 mutations and deletions are associated with disease progression. | PMID: 12406860 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 10.2 | Medium |
| Breast | 8.5 | Medium |
| Colon | 7.1 | Medium |
| Bone Marrow | 6.8 | Low |
| Brain | 4.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| A549 (Lung) | 12.5 | High expression |
| MCF7 (Breast) | 9.8 | Medium expression |
| HCT116 (Colon) | 8.2 | Medium expression |
| K562 (Leukemia) | 6.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | Missense | <1% | Loss of start codon, likely loss of function |
| c.100C>T (p.Arg34*) | Nonsense | <1% | Premature stop, loss of function |
| c.200_201del (p.Glu67fs) | Frameshift | <1% | Frameshift, loss of function |
Mutation functional classification
Loss of Function (LOF)
Most DMTF1 mutations result in loss of function, impairing its tumor suppressor activity.
Gain of Function (GOF)
No gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • transcription factor activity | • RNA polymerase II-specific |
| • DNA-binding transcription factor activity | • protein binding |
| • cyclin binding | • nucleus |
| • regulation of cell cycle | • apoptotic process |
| • negative regulation of cell proliferation |
Pathways
• p53 signaling pathway
• Cell cycle
• Apoptosis
Protein Summary
The DMTF1 protein is a transcription factor that contains a Myb-like DNA-binding domain. It binds to cyclin D and regulates the expression of target genes such as p53, p21, and ARF, thereby controlling cell cycle arrest and apoptosis. DMTF1 acts as a tumor suppressor and is frequently silenced or mutated in human cancers.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| DMTF1 Knockout HEK293 Cell Line | EDJ-KQ6851 | Human | 9988 | Details Get a Quote |
| DMTF1 Knockout A-549 Cell Line | EDJ-KQ31411 | Human | 9988 | Details Get a Quote |
| DMTF1 Knockout HCT 116 Cell Line | EDJ-KQ31412 | Human | 9988 | Details Get a Quote |
| DMTF1 Knockout HeLa Cell Line | EDJ-KQ31413 | Human | 9988 | Details Get a Quote |
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