DHX29 Gene – Function, Expression, Mutations & Disease | Biomedical SEO

DHX29 (DEAH-box helicase 29) encodes a member of the DEAH-box family of RNA helicases. The protein is involved in translation initiation, specifically in the scanning and start codon recognition process, and is essential for efficient mRNA translation, particularly for mRNAs with structured 5' untranslated regions. DHX29 also plays a role in ribosome biogenesis and cell proliferation. Mutations and altered expression of DHX29 have been implicated in various cancers and developmental disorders.

Tissue Expression

Cell Line Expression

Hotspot Mutations

Mutation functional classification

• Eukaryotic translation initiation (Reactome: R-HSA-72649)

• Cap-dependent translation initiation (Reactome: R-HSA-72737)

• Ribosome biogenesis (Reactome: R-HSA-8868773)

DHX29 is a 1369-amino acid DEAH-box RNA helicase that localizes to the cytoplasm and nucleus. It contains a conserved helicase ATP-binding domain and a helicase C-terminal domain. The protein unwinds RNA secondary structures in the 5' UTR of mRNAs, facilitating ribosome scanning and start codon selection. DHX29 interacts with components of the 43S preinitiation complex and is critical for translation of mRNAs with complex 5' UTRs, including many oncogenes. Its expression is elevated in proliferating cells and tumors.