DCN (Decorin)
A small leucine-rich proteoglycan involved in collagen fibril assembly, TGF-beta signaling, and tumor suppression.
Gene Information Card
| Symbol | DCN |
|---|---|
| Full Name | Decorin |
| Gene Type | protein-coding |
| Chromosomal Location | 12q21.33 |
| NCBI Gene ID | 1634 ncbi.nlm.nih.gov/gene/1634 |
| Ensembl ID | ENSG00000011465 |
| UniProt ID | P07585 |
| OMIM ID | 125255 |
| HGNC ID | 2705 |
| Aliases | DSPG2, PG40, PGS2, SLRR1B |
Description
Decorin is a small leucine-rich proteoglycan (SLRP) that binds to collagen fibrils and regulates fibrillogenesis. It modulates growth factor activity, particularly TGF-beta, and acts as a tumor suppressor in various cancers. Decorin is expressed in connective tissues and is involved in wound healing, fibrosis, and angiogenesis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Congenital Stromal Corneal Dystrophy | Loss-of-function mutations in DCN disrupt collagen organization in the cornea, leading to opacity. | ClinVar, OMIM |
| Cancer (multiple types) | Decorin suppresses tumor growth by inhibiting TGF-beta signaling and receptor tyrosine kinases (e.g., EGFR, Met). | COSMIC, NCBI |
| Fibrosis | Decorin neutralizes TGF-beta activity, reducing extracellular matrix deposition in fibrotic tissues. | NCBI, UniProt |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Adipose tissue | 45.2 | Medium |
| Colon | 38.1 | Medium |
| Heart | 22.5 | Low |
| Kidney | 30.8 | Medium |
| Liver | 12.4 | Low |
| Lung | 41.6 | Medium |
| Skin | 62.3 | High |
| Spleen | 8.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| Fibroblasts (primary) | 85.0 | High expression typical of stromal cells |
| HUVEC (endothelial) | 12.3 | Low |
| HeLa (cervical) | 5.6 | Very low |
| A549 (lung) | 18.9 | Low |
| MCF7 (breast) | 3.2 | Very low |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.967C>T (p.Arg323*) | Nonsense | Rare | Premature stop; loss of function associated with corneal dystrophy |
| c.1045C>T (p.Arg349Trp) | Missense | Rare | Altered protein structure; likely pathogenic in corneal dystrophy |
| c.1A>G (p.Met1?) | Start loss | Rare | No protein production; loss of function |
Mutation functional classification
Loss of Function (LOF)
Nonsense and start-loss mutations lead to truncated or absent decorin, impairing collagen fibrillogenesis and TGF-beta regulation.
Gain of Function (GOF)
No documented gain-of-function mutations in DCN.
Dominant Negative (DN)
Missense mutations (e.g., p.Arg349Trp) may exert dominant-negative effects by interfering with collagen binding.
View complete mutation data：
Gene Ontology (GO)
Pathways
• TGF-beta signaling pathway (Reactome: R-HSA-170834)
• Extracellular matrix organization (Reactome: R-HSA-1474244)
• Collagen formation (Reactome: R-HSA-1474290)
Protein Summary
Decorin is a 36.3 kDa proteoglycan with a core protein containing leucine-rich repeats. It binds to collagen type I and II, regulating fibril diameter and assembly. Decorin also interacts with TGF-beta, EGFR, and Met receptors, modulating cell proliferation and migration. Its expression is high in stromal tissues and downregulated in many cancers.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| DCN Knockout HEK293 Cell Line | EDJ-KQ374 | Human | 1634 | Details Get a Quote |
| DCN Knockout HeLa Cell Line | EDJ-KQ18574 | Human | 1634 | Details Get a Quote |
| DCN Knockout A-549 Cell Line | EDJ-KQ61540 | Human | 1634 | Details Get a Quote |
| DCN Knockout HCT 116 Cell Line | EDJ-KQ70033 | Human | 1634 | Details Get a Quote |
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