DACT1 Gene - Dishevelled Binding Antagonist of Beta Catenin 1
Key regulator of Wnt signaling and embryonic development
Gene Information Card
| Symbol | DACT1 |
|---|---|
| Full Name | Dishevelled Binding Antagonist of Beta Catenin 1 |
| Gene Type | Protein coding |
| Chromosomal Location | 14q23.1 |
| NCBI Gene ID | 51339 ncbi.nlm.nih.gov/gene/51339 |
| Ensembl ID | ENSG00000100823 |
| UniProt ID | Q9NYF0 |
| OMIM ID | 607861 |
| HGNC ID | 17748 |
| Aliases | DAPPER1, DPR1, HDPR1, THYEX3 |
Description
DACT1 (Dishevelled Binding Antagonist of Beta Catenin 1) is a protein-coding gene that plays a critical role in regulating the Wnt signaling pathway. It encodes a protein that binds to Dishevelled (DVL) proteins, thereby inhibiting beta-catenin-mediated transcription. DACT1 is involved in embryonic development, cell proliferation, and differentiation. Dysregulation of DACT1 has been implicated in various cancers and developmental disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal cancer | DACT1 downregulation leads to increased Wnt/beta-catenin signaling, promoting tumorigenesis | PMID: 19029980 |
| Hepatocellular carcinoma | Reduced DACT1 expression correlates with poor prognosis and enhanced metastasis | PMID: 23361059 |
| Gastric cancer | DACT1 promoter methylation silences expression, activating Wnt signaling | PMID: 22961667 |
| Breast cancer | DACT1 loss contributes to epithelial-mesenchymal transition and invasion | PMID: 25695636 |
| Neural tube defects | DACT1 mutations disrupt Wnt planar cell polarity pathway | PMID: 23354437 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Heart | 8.3 | Low |
| Liver | 6.1 | Low |
| Kidney | 15.2 | Medium |
| Lung | 9.8 | Low |
| Placenta | 20.4 | High |
| Testis | 18.7 | High |
| Ovary | 14.1 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 22.5 | High expression |
| HeLa | 15.3 | Medium expression |
| HepG2 | 8.7 | Low expression |
| MCF7 | 12.1 | Medium expression |
| A549 | 10.4 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1072C>T (p.Arg358Trp) | Missense | Rare | Alters protein function; associated with neural tube defects |
| c.1465G>A (p.Glu489Lys) | Missense | Rare | Potential loss of function in Wnt signaling |
| c.1234delC | Frameshift | Very rare | Truncated protein; loss of DVL binding |
Mutation functional classification
Loss of Function (LOF)
Mutations that impair DACT1 binding to Dishevelled or reduce protein stability, leading to unchecked Wnt/beta-catenin signaling.
Gain of Function (GOF)
Not well characterized; no common gain-of-function mutations reported.
Dominant Negative (DN)
Truncating mutations that interfere with wild-type DACT1 function, potentially disrupting Wnt planar cell polarity.
View complete mutation data：
Gene Ontology (GO)
| • Wnt signaling pathway | • negative regulation of canonical Wnt signaling pathway |
| • protein binding | • cytoplasm |
| • nucleus | • Dishevelled binding |
Pathways
• Wnt signaling pathway (KEGG: hsa04310)
• Planar cell polarity pathway
• Beta-catenin destruction complex
Protein Summary
The DACT1 protein is a 750-amino acid cytoplasmic and nuclear protein that functions as a negative regulator of the canonical Wnt signaling pathway. It directly binds to Dishevelled (DVL) proteins, promoting their degradation and preventing beta-catenin stabilization. DACT1 also participates in non-canonical Wnt signaling, including planar cell polarity. The protein contains conserved domains for DVL interaction and nuclear localization signals. Altered expression or mutations in DACT1 contribute to developmental defects and cancer progression.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| DACT1 Knockout HEK293 Cell Line | EDJ-KQ11060 | Human | 51339 | Details Get a Quote |
| DACT1 Knockout HCT 116 Cell Line | EDJ-KQ38981 | Human | 51339 | Details Get a Quote |
| DACT1 Knockout HeLa Cell Line | EDJ-KQ56292 | Human | 51339 | Details Get a Quote |
| DACT1 Knockout A-549 Cell Line | EDJ-KQ64781 | Human | 51339 | Details Get a Quote |
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