CXCL11: C-X-C Motif Chemokine Ligand 11
A key chemokine in immune response and inflammation
Gene Information Card
| Symbol | CXCL11 |
|---|---|
| Full Name | C-X-C Motif Chemokine Ligand 11 |
| Gene Type | Protein coding |
| Chromosomal Location | 4q21.1 |
| NCBI Gene ID | 6373 ncbi.nlm.nih.gov/gene/6373 |
| Ensembl ID | ENSG00000169248 |
| UniProt ID | O14625 |
| OMIM ID | 604852 |
| HGNC ID | 10637 |
| Aliases | I-TAC, SCYB9B, SCYB11, b-R1, H174 |
Description
CXCL11 (C-X-C Motif Chemokine Ligand 11) is a chemokine gene located on chromosome 4q21.1. It encodes a small cytokine belonging to the CXC chemokine family. CXCL11 is a ligand for the chemokine receptor CXCR3 and is involved in chemoattraction of activated T cells, NK cells, and other immune cells. It plays a role in inflammatory responses, viral infection, and tumor immunity.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Inflammatory bowel disease | CXCL11 recruits CXCR3+ T cells to inflamed intestinal mucosa | PMID: 19029978 |
| Rheumatoid arthritis | Overexpression in synovial tissue promotes T cell infiltration | PMID: 15657133 |
| Psoriasis | Elevated CXCL11 in skin lesions drives T cell chemotaxis | PMID: 12626704 |
| HIV infection | CXCL11 inhibits HIV entry by competing for CXCR3 binding | PMID: 10523647 |
| Cancer (various) | CXCL11 expression correlates with tumor-infiltrating lymphocytes and prognosis | PMID: 21880737 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lymph node | 12.5 | High |
| Spleen | 10.2 | High |
| Lung | 8.7 | Medium |
| Small intestine | 7.3 | Medium |
| Thymus | 6.1 | Medium |
| Liver | 2.4 | Low |
| Brain | 0.5 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| THP-1 (monocyte) | 15.3 | IFN-gamma stimulated |
| Jurkat (T cell) | 8.9 | Activated |
| HeLa (cervical) | 4.2 | Basal expression |
| A549 (lung) | 6.7 | TNF-alpha induced |
| HUVEC (endothelial) | 3.1 | IFN-gamma stimulated |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | 0.01% | Reduced chemotactic activity |
| c.101C>T | Nonsense | 0.005% | Premature truncation, loss of function |
| c.205G>A | Missense | 0.02% | Altered receptor binding |
Mutation functional classification
Loss of Function (LOF)
Nonsense mutations (e.g., c.101C>T) lead to truncated protein with impaired chemotaxis.
Gain of Function (GOF)
Not reported in literature.
Dominant Negative (DN)
Not reported in literature.
View complete mutation data：
Gene Ontology (GO)
| • chemokine activity (GO:0008009) | • immune response (GO:0006955) |
| • chemotaxis (GO:0006935) | • chemokine-mediated signaling pathway (GO:0070098) |
| • extracellular space (GO:0005615) |
Pathways
• Chemokine signaling pathway (KEGG: hsa04062)
• Cytokine-cytokine receptor interaction (KEGG: hsa04060)
• Toll-like receptor signaling pathway (KEGG: hsa04620)
Protein Summary
CXCL11 (I-TAC) is a 94-amino acid secreted chemokine that binds specifically to CXCR3. It is induced by interferon-gamma and plays a critical role in recruiting activated T cells, NK cells, and dendritic cells to sites of inflammation. The protein structure includes a typical CXC motif with two conserved cysteine residues. CXCL11 is involved in autoimmune diseases, viral infections, and antitumor immunity.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CXCL11 Knockout HEK293 Cell Line | EDJ-KQ50615 | Human | 6373 | Details Get a Quote |
| CXCL11 Knockout HeLa Cell Line | EDJ-KQ54433 | Human | 6373 | Details Get a Quote |
| CXCL11 Knockout A-549 Cell Line | EDJ-KQ62921 | Human | 6373 | Details Get a Quote |
| CXCL11 Knockout HCT 116 Cell Line | EDJ-KQ71390 | Human | 6373 | Details Get a Quote |
