CTDSPL
CTD Small Phosphatase Like
Gene Information Card
| Symbol | CTDSPL |
|---|---|
| Full Name | CTD Small Phosphatase Like |
| Gene Type | protein-coding |
| Chromosomal Location | 3p21.3 |
| NCBI Gene ID | 10217 ncbi.nlm.nih.gov/gene/10217 |
| Ensembl ID | ENSG00000144677 |
| UniProt ID | Q15194 |
| OMIM ID | 608592 |
| HGNC ID | 16886 |
| Aliases | SCP3, HYA22, C3orf8 |
Description
CTDSPL (CTD Small Phosphatase Like) encodes a member of the small CTD phosphatase family. The protein dephosphorylates the C-terminal domain of RNA polymerase II, regulating transcription. It is located on chromosome 3p21.3, a region frequently deleted in cancers, suggesting a tumor suppressor role.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Lung Cancer | Loss of heterozygosity at 3p21.3 may reduce CTDSPL expression, contributing to tumorigenesis. | NCBI Gene, OMIM |
| Renal Cell Carcinoma | Decreased expression observed; potential tumor suppressor. | NCBI Gene |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Brain | 8.2 | Low |
| Lung | 6.1 | Low |
| Kidney | 5.4 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 10.3 | Embryonic kidney |
| HeLa | 7.8 | Cervical cancer |
| A549 | 5.2 | Lung cancer |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | <0.1% | Unknown significance |
| c.200C>T | Nonsense | <0.1% | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Nonsense mutations may lead to truncated protein and loss of phosphatase activity.
Gain of Function (GOF)
Not reported.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
| • phosphoprotein phosphatase activity | • RNA polymerase II CTD heptapeptide repeat phosphatase activity |
| • nucleus | • cytoplasm |
| • regulation of transcription by RNA polymerase II |
Pathways
• RNA polymerase II transcription termination
Protein Summary
CTDSPL is a 261-amino acid protein with a molecular weight of ~29 kDa. It contains a haloacid dehalogenase (HAD)-like domain and specifically dephosphorylates Ser5 of the RNA polymerase II CTD. It is localized in the nucleus and cytoplasm.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CTDSPL Knockout HEK293 Cell Line | EDJ-KQ6959 | Human | 10217 | Details Get a Quote |
| CTDSPL2 Knockout HEK293 Cell Line | EDJ-KQ11113 | Human | 51496 | Details Get a Quote |
| CTDSPL2 Knockout A-549 Cell Line | EDJ-KQ39087 | Human | 51496 | Details Get a Quote |
| CTDSPL2 Knockout HCT 116 Cell Line | EDJ-KQ39088 | Human | 51496 | Details Get a Quote |
| CTDSPL2 Knockout HeLa Cell Line | EDJ-KQ39089 | Human | 51496 | Details Get a Quote |
| CTDSPL Knockout A-549 Cell Line | EDJ-KQ31634 | Human | 10217 | Details Get a Quote |
| CTDSPL Knockout HCT 116 Cell Line | EDJ-KQ31635 | Human | 10217 | Details Get a Quote |
| CTDSPL Knockout HeLa Cell Line | EDJ-KQ31636 | Human | 10217 | Details Get a Quote |
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