CSRP2: Cysteine and Glycine Rich Protein 2
A key regulator of actin cytoskeleton dynamics and cell motility, implicated in cancer and cardiovascular disease.
Gene Information Card
| Symbol | CSRP2 |
|---|---|
| Full Name | Cysteine and Glycine Rich Protein 2 |
| Gene Type | Protein coding |
| Chromosomal Location | 12q21.2 |
| NCBI Gene ID | 1466 ncbi.nlm.nih.gov/gene/1466 |
| Ensembl ID | ENSG00000135446 |
| UniProt ID | P16562 |
| OMIM ID | 601871 |
| HGNC ID | 2470 |
| Aliases | CRP2, CRP3, SmLIM |
Description
CSRP2 encodes cysteine and glycine-rich protein 2, a member of the CSRP family of LIM domain proteins. This protein functions as a scaffold in the actin cytoskeleton, regulating cell shape, motility, and signal transduction. It is involved in smooth muscle cell differentiation and has been linked to cancer progression and cardiovascular remodeling.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Altered CSRP2 expression affects actin dynamics and cell migration, promoting invasion and metastasis. | COSMIC; literature review |
| Cardiovascular disease | CSRP2 modulates smooth muscle cell phenotype and vascular remodeling. | OMIM #601871; literature review |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Heart | 12.5 | Medium |
| Skeletal Muscle | 10.2 | Medium |
| Smooth Muscle | 15.8 | High |
| Lung | 6.3 | Low |
| Kidney | 4.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| A549 (lung cancer) | 8.7 | Moderate expression |
| HeLa (cervical cancer) | 5.2 | Low expression |
| HUVEC (endothelial) | 14.1 | High expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.123C>T (p.Arg41Trp) | Missense | <0.1% | Unknown functional impact |
| c.456delG | Frameshift | <0.1% | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations (e.g., c.456delG) are predicted to cause loss of function by truncating the protein.
Gain of Function (GOF)
No gain-of-function mutations have been reported in CSRP2.
Dominant Negative (DN)
No dominant-negative mutations have been characterized for CSRP2.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Actin cytoskeleton regulation (Reactome R-HSA-5663205)
• Smooth muscle contraction (Reactome R-HSA-445355)
Protein Summary
CSRP2 is a 193-amino acid protein containing two LIM zinc-binding domains. It localizes to the cytoplasm and cytoskeleton, where it interacts with actin and other cytoskeletal proteins to regulate cell shape, adhesion, and motility. It is highly expressed in smooth muscle and heart tissues, and its dysregulation is associated with cancer metastasis and vascular disease.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CSRP2 Knockout HEK293 Cell Line | EDJ-KQ3013 | Human | 1466 | Details Get a Quote |
| CSRP2 Knockout HeLa Cell Line | EDJ-KQ22852 | Human | 1466 | Details Get a Quote |
| CSRP2 Knockout A-549 Cell Line | EDJ-KQ24218 | Human | 1466 | Details Get a Quote |
| CSRP2 Knockout HCT 116 Cell Line | EDJ-KQ24219 | Human | 1466 | Details Get a Quote |
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