CRTAC1: Cartilage Acidic Protein 1
Extracellular Matrix Protein in Cartilage and Cancer
Gene Information Card
| Symbol | CRTAC1 |
|---|---|
| Full Name | Cartilage Acidic Protein 1 |
| Gene Type | Protein coding |
| Chromosomal Location | 10q24.2 |
| NCBI Gene ID | 55118 ncbi.nlm.nih.gov/gene/55118 |
| Ensembl ID | ENSG00000120071 |
| UniProt ID | Q9NQ79 |
| OMIM ID | 617174 |
| HGNC ID | 14882 |
| Aliases | ASPIC1, CEP-68, LOTUS, UNQ236/PRO269 |
Description
CRTAC1 encodes a secreted extracellular matrix protein predominantly expressed in cartilage. It contains a C-type lectin domain and is involved in cell adhesion and matrix organization. The protein is also found in brain and is implicated in osteogenesis and cancer progression.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Osteoarthritis | Altered CRTAC1 expression may disrupt cartilage extracellular matrix integrity, contributing to joint degeneration. | PMID: 25604813 |
| Breast cancer | CRTAC1 is hypermethylated and downregulated in breast cancer, suggesting a tumor suppressor role. | PMID: 23943740 |
| Lung adenocarcinoma | CRTAC1 expression is associated with immune infiltration and prognosis. | PMID: 32943678 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Cartilage | 12.5 | High |
| Brain | 8.2 | Medium |
| Lung | 3.1 | Low |
| Breast | 1.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| SW1353 (chondrosarcoma) | 15.0 | High expression |
| MCF7 (breast cancer) | 0.5 | Low expression |
| A549 (lung cancer) | 2.3 | Moderate expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1015C>T (p.Arg339Trp) | Missense | <0.01% | Unknown functional impact |
| c.1246G>A (p.Gly416Ser) | Missense | <0.01% | Reported in COSMIC |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • extracellular region | • extracellular matrix |
| • calcium ion binding | • cell adhesion |
| • carbohydrate binding |
Pathways
• ECM-receptor interaction
• Protein digestion and absorption
Protein Summary
CRTAC1 is a 661-amino acid secreted protein with a signal peptide, a C-type lectin domain, and a C-terminal cysteine-rich region. It is glycosylated and forms disulfide-linked dimers. The protein binds calcium and mediates cell-matrix interactions.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CRTAC1 Knockout HEK293 Cell Line | EDJ-KQ13006 | Human | 55118 | Details Get a Quote |
| CRTAC1 Knockout HeLa Cell Line | EDJ-KQ42266 | Human | 55118 | Details Get a Quote |
| CRTAC1 Knockout A-549 Cell Line | EDJ-KQ65036 | Human | 55118 | Details Get a Quote |
| CRTAC1 Knockout HCT 116 Cell Line | EDJ-KQ73481 | Human | 55118 | Details Get a Quote |
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