CRK Gene - CRK Proto-Oncogene, Adaptor Protein
Comprehensive biomedical resource for CRK: genomic data, expression, mutations, and disease associations.
Gene Information Card
| Symbol | CRK |
|---|---|
| Full Name | CRK proto-oncogene, adaptor protein |
| Gene Type | protein-coding |
| Chromosomal Location | 17p13.3 |
| NCBI Gene ID | 1398 ncbi.nlm.nih.gov/gene/1398 |
| Ensembl ID | ENSG00000167193 |
| UniProt ID | P46108 |
| OMIM ID | 164762 |
| HGNC ID | 2362 |
| Aliases | CRKII, p38, CRK-I, CRK-II |
Description
The CRK gene encodes a member of the CRK family of adaptor proteins that contain SH2 and SH3 domains. This protein is involved in multiple signaling pathways, including those regulating cell proliferation, migration, and differentiation. It interacts with tyrosine-phosphorylated proteins and mediates signal transduction from receptor tyrosine kinases to downstream effectors. CRK is implicated in various cancers and developmental processes.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Lung Cancer | CRK overexpression enhances cell migration and invasion via integrin signaling | PMID: 23454750 |
| Breast Cancer | CRK amplification and overexpression promote tumor growth and metastasis | PMID: 25609832 |
| Colorectal Cancer | CRK upregulation correlates with poor prognosis and activates MAPK pathway | PMID: 27121325 |
| Glioblastoma | CRK signaling through FAK and p130Cas drives invasion | PMID: 21947069 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 12.3 | Medium |
| Breast | 8.7 | Low |
| Colon | 15.1 | Medium |
| Brain | 6.2 | Low |
| Liver | 9.4 | Low |
| Kidney | 11.0 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| A549 (lung cancer) | 18.5 | High expression |
| MCF7 (breast cancer) | 14.2 | Medium expression |
| HCT116 (colorectal cancer) | 22.1 | High expression |
| U87MG (glioblastoma) | 16.8 | High expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.497G>A (p.Arg166Gln) | Missense | <0.1% | Altered SH3 domain binding |
| c.112C>T (p.Arg38Trp) | Missense | <0.1% | Reduced SH2 domain affinity |
| c.1A>G (p.Met1Val) | Start loss | <0.1% | Loss of protein expression |
| c.345_346insA | Frameshift | <0.1% | Truncated protein, loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift and start-loss mutations lead to truncated or absent protein, impairing adaptor function.
Gain of Function (GOF)
Missense mutations in SH2/SH3 domains may alter binding specificity, potentially enhancing oncogenic signaling.
Dominant Negative (DN)
Some mutations produce truncated proteins that interfere with wild-type CRK signaling.
View complete mutation data：
Gene Ontology (GO)
| • SH3/SH2 adaptor activity (GO:0005070) | • signal transduction (GO:0007165) |
| • cell differentiation (GO:0030154) | • neurotrophin TRK receptor signaling pathway (GO:0048011) |
| • positive regulation of cell population proliferation (GO:0008284) | • cell migration (GO:0016477) |
Pathways
• ErbB signaling pathway (KEGG: hsa04012)
• Focal adhesion (KEGG: hsa04510)
• Rap1 signaling pathway (KEGG: hsa04015)
• Signaling by Receptor Tyrosine Kinases (Reactome: R-HSA-9006934)
Protein Summary
CRK is a 38 kDa adaptor protein composed of one SH2 domain and two SH3 domains (N-terminal and C-terminal). It lacks intrinsic enzymatic activity but mediates protein-protein interactions in signaling cascades. The SH2 domain binds phosphotyrosine motifs on activated receptors or docking proteins, while SH3 domains recruit proline-rich effectors such as C3G, DOCK1, and ABL1. CRK is ubiquitously expressed and plays roles in cell adhesion, migration, and proliferation. Alternative splicing generates isoforms CRK-I and CRK-II, with CRK-II containing an additional C-terminal SH3 domain.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CRK Knockout HEK293 Cell Line | EDJ-KQ634 | Human | 1398 | Details Get a Quote |
| CRK Knockout HCT 116 Cell Line | EDJ-KQ19103 | Human | 1398 | Details Get a Quote |
| CRK Knockout HeLa Cell Line | EDJ-KQ19104 | Human | 1398 | Details Get a Quote |
| CRK Knockout A-549 Cell Line | EDJ-KQ61449 | Human | 1398 | Details Get a Quote |
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