CRISP3: Cysteine-Rich Secretory Protein 3
A member of the CRISP family involved in innate immunity and male reproductive function
Gene Information Card
| Symbol | CRISP3 |
|---|---|
| Full Name | Cysteine-Rich Secretory Protein 3 |
| Gene Type | Protein coding |
| Chromosomal Location | 6p12.3 |
| NCBI Gene ID | 10321 ncbi.nlm.nih.gov/gene/10321 |
| Ensembl ID | ENSG00000112210 |
| UniProt ID | P54108 |
| OMIM ID | 618092 |
| HGNC ID | 2366 |
| Aliases | CRISP-3, SGP28, dJ442L6.1 |
Description
CRISP3 encodes a cysteine-rich secretory protein (CRISP) family member predominantly expressed in the male reproductive tract, salivary glands, and neutrophils. The protein is involved in host defense, sperm maturation, and modulation of ion channel activity. CRISP3 is upregulated in prostate cancer and other inflammatory conditions.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Prostate cancer | Overexpression of CRISP3 in prostate epithelium correlates with tumor aggressiveness and androgen independence | PMID: 15604206; NCBI Gene |
| Salivary gland tumors | CRISP3 is a marker for acinic cell carcinoma and adenoid cystic carcinoma | PMID: 18697828; UniProt |
| Male infertility | Altered CRISP3 levels in seminal plasma may affect sperm function | PMID: 11532963; OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Prostate | 42.3 | High |
| Salivary gland | 38.1 | High |
| Epididymis | 35.7 | High |
| Bone marrow | 12.5 | Medium |
| Lung | 2.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| PC-3 (prostate cancer) | 45.6 | Androgen-independent line |
| LNCaP (prostate cancer) | 28.3 | Androgen-sensitive |
| HL-60 (promyeloblast) | 15.2 | Neutrophil-like differentiation |
| HeLa (cervical) | 1.8 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.256G>A (p.Gly86Arg) | Missense | <0.1% | Unknown functional impact; reported in COSMIC |
| c.424C>T (p.Arg142Cys) | Missense | <0.1% | Potential disulfide bond disruption; ClinVar uncertain significance |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function variants reported in CRISP3.
Gain of Function (GOF)
Overexpression in prostate cancer suggests potential gain-of-function role in tumor progression.
Dominant Negative (DN)
No dominant-negative mutations described.
View complete mutation data：
Gene Ontology (GO)
Pathways
• REACT:14797 (Innate Immune System)
• REACT:14798 (Neutrophil degranulation)
Protein Summary
CRISP3 is a 245-amino acid secreted glycoprotein containing a CAP (cysteine-rich secretory protein, antigen 5, and pathogenesis-related 1) domain and a C-terminal CRISP domain. It is stored in neutrophil-specific granules and released upon activation. The protein modulates calcium and potassium ion channels, contributing to sperm capacitation and antimicrobial defense.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CRISP3 Knockout HEK293 Cell Line | EDJ-KQ7005 | Human | 10321 | Details Get a Quote |
| CRISP3 Knockout HeLa Cell Line | EDJ-KQ55377 | Human | 10321 | Details Get a Quote |
| CRISP3 Knockout A-549 Cell Line | EDJ-KQ63859 | Human | 10321 | Details Get a Quote |
| CRISP3 Knockout HCT 116 Cell Line | EDJ-KQ72316 | Human | 10321 | Details Get a Quote |
