CPA2 Gene - Carboxypeptidase A2
A comprehensive resource on CPA2, including genomic data, expression, and disease associations.
Gene Information Card
| Symbol | CPA2 |
|---|---|
| Full Name | Carboxypeptidase A2 |
| Gene Type | protein-coding |
| Chromosomal Location | 7q32.2 |
| NCBI Gene ID | 1358 ncbi.nlm.nih.gov/gene/1358 |
| Ensembl ID | ENSG00000158516 |
| UniProt ID | P48052 |
| OMIM ID | 603504 |
| HGNC ID | 2297 |
| Aliases | CPA2_HUMAN |
Description
CPA2 (Carboxypeptidase A2) is a protein-coding gene located on chromosome 7q32.2. It encodes a pancreatic metallocarboxypeptidase that cleaves C-terminal aromatic and aliphatic amino acids from dietary proteins, playing a key role in digestion. The enzyme is secreted as a zymogen and activated by trypsin.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Pancreatitis | Impaired CPA2 activity may contribute to autodigestion and inflammation of the pancreas. | PMID: 12368274 |
| Pancreatic cancer | Altered CPA2 expression has been observed in pancreatic ductal adenocarcinoma. | PMID: 25691885 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Pancreas | 127.2 | High |
| Duodenum | 4.5 | Low |
| Stomach | 1.2 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| PANC-1 | 0.8 | Low expression in pancreatic cancer cell line |
| Capan-2 | 1.5 | Moderate expression |
| BxPC-3 | 0.6 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.112G>A (p.Gly38Arg) | missense | <0.01% | Unknown functional impact |
| c.421C>T (p.Arg141Trp) | missense | <0.01% | Predicted damaging |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • metallocarboxypeptidase activity (GO:0004181) | • proteolysis (GO:0006508) |
| • extracellular space (GO:0005615) | • metal ion binding (GO:0046872) |
Pathways
• Digestion of dietary protein (Reactome: R-HSA-8963748)
• Pancreatic secretion (KEGG: hsa04972)
Protein Summary
Carboxypeptidase A2 is a 417-amino-acid protein (UniProt P48052) synthesized as a preproenzyme in pancreatic acinar cells. After signal peptide cleavage, the proenzyme is activated by trypsin. The mature enzyme contains one zinc ion per subunit and specifically hydrolyzes C-terminal aromatic (Phe, Tyr, Trp) and aliphatic (Leu, Ile, Met) residues. It is a key component of the pancreatic digestive enzyme cocktail.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CPA2 Knockout HEK293 Cell Line | EDJ-KQ4326 | Human | 1358 | Details Get a Quote |
| CPA2 Knockout HeLa Cell Line | EDJ-KQ52967 | Human | 1358 | Details Get a Quote |
| CPA2 Knockout A-549 Cell Line | EDJ-KQ61435 | Human | 1358 | Details Get a Quote |
| CPA2 Knockout HCT 116 Cell Line | EDJ-KQ69931 | Human | 1358 | Details Get a Quote |
