COPS2: COP9 Signalosome Subunit 2
A core component of the COP9 signalosome complex involved in protein degradation and gene regulation
Gene Information Card
| Symbol | COPS2 |
|---|---|
| Full Name | COP9 signalosome subunit 2 |
| Gene Type | protein-coding |
| Chromosomal Location | 15q21.2 |
| NCBI Gene ID | 9318 ncbi.nlm.nih.gov/gene/9318 |
| Ensembl ID | ENSG00000166226 |
| UniProt ID | P61201 |
| OMIM ID | 604498 |
| HGNC ID | 2239 |
| Aliases | CSN2, SGN2, TRIP15, ALIEN |
Description
COPS2 encodes subunit 2 of the COP9 signalosome (CSN), a multiprotein complex that regulates the ubiquitin-proteasome pathway by controlling the activity of cullin-RING E3 ubiquitin ligases. CSN2 is essential for deneddylation of cullins, thereby modulating protein degradation, cell cycle progression, and signal transduction. It also functions as a transcriptional corepressor via interaction with nuclear receptors and other transcription factors.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Hepatocellular carcinoma | COPS2 overexpression promotes cullin deneddylation, stabilizing oncoproteins and enhancing cell proliferation | PMID: 25605247 |
| Breast cancer | COPS2 upregulation correlates with poor prognosis; modulates estrogen receptor signaling | PMID: 21502514 |
| Lung cancer | COPS2 knockdown reduces tumor growth via impaired CRL activity | PMID: 27323850 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 18.5 | High |
| Brain | 12.3 | Medium |
| Liver | 10.1 | Medium |
| Heart | 8.7 | Medium |
| Lung | 7.4 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 15.2 | Embryonic kidney; high expression |
| HeLa | 13.8 | Cervical carcinoma; moderate |
| A549 | 11.5 | Lung carcinoma; moderate |
| MCF7 | 9.9 | Breast carcinoma; moderate |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.497C>T (p.Thr166Ile) | Missense | <0.01% | Unknown; rare variant in COSMIC |
| c.832G>A (p.Glu278Lys) | Missense | <0.01% | Reported in COSMIC; functional impact unclear |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in major databases.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
Pathways
• COP9 signalosome (KEGG: hsa03050)
• Ubiquitin mediated proteolysis (KEGG: hsa04120)
• Protein processing in endoplasmic reticulum (KEGG: hsa04141)
Protein Summary
COPS2 (CSN2) is a 443-amino acid protein that forms an integral part of the COP9 signalosome complex. It contains a PCI domain that mediates complex assembly. CSN2 is required for the deneddylation of cullin proteins, which inactivates cullin-RING E3 ligases and prevents premature substrate ubiquitination. Additionally, CSN2 acts as a transcriptional corepressor by recruiting histone deacetylases to nuclear receptors such as thyroid hormone receptor and retinoic acid receptor. Its dual role in proteolysis and transcription links it to cell growth, differentiation, and cancer.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| COPS2 Knockout HEK293 Cell Line | EDJ-KQ50861 | Human | 9318 | Details Get a Quote |
| COPS2 Knockout HeLa Cell Line | EDJ-KQ55127 | Human | 9318 | Details Get a Quote |
| COPS2 Knockout A-549 Cell Line | EDJ-KQ63607 | Human | 9318 | Details Get a Quote |
| COPS2 Knockout HCT 116 Cell Line | EDJ-KQ72071 | Human | 9318 | Details Get a Quote |
