CNPY1: Canopy FGF Signaling Regulator 1
A gene encoding a secreted protein involved in fibroblast growth factor signaling and cellular stress responses.
Gene Information Card
| Symbol | CNPY1 |
|---|---|
| Full Name | Canopy FGF Signaling Regulator 1 |
| Gene Type | Protein coding |
| Chromosomal Location | 7q22.1 |
| NCBI Gene ID | 125061 ncbi.nlm.nih.gov/gene/125061 |
| Ensembl ID | ENSG00000106333 |
| UniProt ID | Q9Y6M0 |
| OMIM ID | 610422 |
| HGNC ID | 24301 |
| Aliases | ZNF436, FLJ10305, MGC131891 |
Description
CNPY1 (Canopy FGF Signaling Regulator 1) encodes a secreted protein that modulates fibroblast growth factor (FGF) signaling by binding to FGF ligands and regulating their bioavailability. The protein is also implicated in endoplasmic reticulum (ER) stress responses and may play a role in cell proliferation and differentiation. CNPY1 is expressed in various tissues, with notable levels in the brain and testis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association confirmed | Not established | No curated disease entries in OMIM or ClinVar as of 2025 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Testis | 8.3 | Medium |
| Lung | 4.1 | Low |
| Liver | 2.0 | Low |
| Heart | 1.5 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 15.2 | Moderate expression |
| HeLa | 10.8 | Moderate expression |
| K562 | 6.4 | Low expression |
| A549 | 5.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.337C>T (p.Arg113Trp) | Missense | <0.01% | Unknown functional impact |
| c.482G>A (p.Arg161Gln) | Missense | <0.01% | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in curated databases.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
Pathways
• FGF signaling pathway (Reactome: R-HSA-190236)
• Unfolded Protein Response (UPR) (Reactome: R-HSA-381119)
Protein Summary
CNPY1 is a secreted protein of 346 amino acids (UniProt Q9Y6M0) that contains a signal peptide and a canopy domain. It functions as a modulator of FGF signaling by interacting with FGF ligands and regulating their extracellular availability. Additionally, CNPY1 is involved in the unfolded protein response (UPR) during ER stress, potentially influencing cell survival and apoptosis. The protein is expressed in multiple tissues, with highest levels in brain and testis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CNPY1 Knockout HEK293 Cell Line | EDJ-KQ12965 | Human | 285888 | Details Get a Quote |
| CNPY1 Knockout HeLa Cell Line | EDJ-KQ59537 | Human | 285888 | Details Get a Quote |
| CNPY1 Knockout A-549 Cell Line | EDJ-KQ68005 | Human | 285888 | Details Get a Quote |
| CNPY1 Knockout HCT 116 Cell Line | EDJ-KQ76383 | Human | 285888 | Details Get a Quote |
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