CMTM3
CKLF-like MARVEL transmembrane domain-containing protein 3
Gene Information Card
| Symbol | CMTM3 |
|---|---|
| Full Name | CKLF-like MARVEL transmembrane domain-containing protein 3 |
| Gene Type | protein-coding |
| Chromosomal Location | 16q21 |
| NCBI Gene ID | 123920 ncbi.nlm.nih.gov/gene/123920 |
| Ensembl ID | ENSG00000140931 |
| UniProt ID | Q96L33 |
| OMIM ID | 607889 |
| HGNC ID | 19172 |
| Aliases | CKLFSF3, MARVELD3 |
Description
CMTM3 (CKLF-like MARVEL transmembrane domain-containing protein 3) is a member of the CMTM gene family, which encodes proteins with a MARVEL (MAL and related proteins for vesicle trafficking and membrane link) domain. CMTM3 is involved in chemokine-like signaling, immune modulation, and tumor suppression. It is located on chromosome 16q21 and is expressed in various tissues, with roles in cell migration, proliferation, and apoptosis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Hepatocellular carcinoma | Downregulation of CMTM3 promotes tumor growth and metastasis via activation of AKT signaling | PMID: 25944712 |
| Gastric cancer | CMTM3 acts as a tumor suppressor; reduced expression correlates with poor prognosis | PMID: 24743142 |
| Prostate cancer | CMTM3 inhibits cell proliferation and invasion through regulation of EMT markers | PMID: 27323861 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Lung | 8.3 | Medium |
| Kidney | 7.1 | Medium |
| Liver | 4.2 | Low |
| Brain | 2.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 5.6 | Hepatocellular carcinoma cell line |
| A549 | 4.3 | Lung adenocarcinoma cell line |
| PC3 | 3.9 | Prostate cancer cell line |
| MCF7 | 2.1 | Breast cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.256C>T (p.Arg86Trp) | Missense | <0.01% | Unknown functional impact |
| c.421G>A (p.Gly141Ser) | Missense | <0.01% | Reported in COSMIC database |
Mutation functional classification
Loss of Function (LOF)
Reduced expression or loss of CMTM3 is associated with tumor progression in multiple cancers.
Gain of Function (GOF)
No documented gain-of-function mutations.
Dominant Negative (DN)
No evidence of dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • GO:0005886 (GO:0005886) | • GO:0005515 (GO:0005515) |
| • GO:0043066 (GO:0043066) | • GO:0008285 (GO:0008285) |
| • GO:0007165 (GO:0007165) |
Pathways
• PI3K-Akt signaling pathway
• Apoptosis
• Cell cycle
Protein Summary
CMTM3 encodes a 182-amino acid protein with a MARVEL domain, predicted to localize to the plasma membrane and vesicles. It is involved in chemokine-like activity, regulating cell migration and immune responses. The protein is downregulated in several cancers, suggesting a tumor suppressor role.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CMTM3 Knockout HEK293 Cell Line | EDJ-KQ463 | Human | 123920 | Details Get a Quote |
| CMTM3 Knockout A-549 Cell Line | EDJ-KQ20104 | Human | 123920 | Details Get a Quote |
| CMTM3 Knockout HCT 116 Cell Line | EDJ-KQ20105 | Human | 123920 | Details Get a Quote |
| CMTM3 Knockout HeLa Cell Line | EDJ-KQ20106 | Human | 123920 | Details Get a Quote |
