CMKLR1 (Chemokine Like Receptor 1)
Atypical chemokine receptor involved in inflammation, adipogenesis, and cancer
Gene Information Card
| Symbol | CMKLR1 |
|---|---|
| Full Name | Chemokine Like Receptor 1 |
| Gene Type | protein-coding |
| Chromosomal Location | 12q23.3 |
| NCBI Gene ID | 1240 ncbi.nlm.nih.gov/gene/1240 |
| Ensembl ID | ENSG00000174600 |
| UniProt ID | Q99731 |
| OMIM ID | 602351 |
| HGNC ID | 2117 |
| Aliases | GPR1, DEZ, ChemR23 |
Description
CMKLR1 (Chemokine Like Receptor 1) encodes a G protein-coupled receptor that binds chemerin (RARRES2) and is involved in immune cell chemotaxis, adipocyte differentiation, and metabolic regulation. The receptor is expressed on dendritic cells, macrophages, and adipocytes, and plays roles in inflammation, obesity, and cancer progression.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Obesity | CMKLR1 mediates chemerin signaling in adipocytes, influencing adipogenesis and lipid metabolism. Variants may alter receptor function and contribute to obesity risk. | ClinVar, NCBI Gene |
| Type 2 Diabetes | Chemerin/CMKLR1 axis modulates insulin sensitivity and glucose homeostasis. Dysregulation is associated with insulin resistance. | NCBI Gene, UniProt |
| Inflammatory Diseases | CMKLR1 promotes chemotaxis of dendritic cells and macrophages to sites of inflammation. Overexpression linked to chronic inflammatory conditions. | NCBI Gene, OMIM |
| Cancer (various) | CMKLR1 expression is altered in several cancers (e.g., breast, colorectal, melanoma), affecting tumor growth, angiogenesis, and metastasis. | COSMIC, NCBI Gene |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Adipose tissue | 12.5 | Medium |
| Lung | 8.3 | Low |
| Spleen | 6.7 | Low |
| Bone marrow | 5.2 | Low |
| Liver | 2.1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| THP-1 (monocyte) | 15.0 | High expression |
| HepG2 (hepatocyte) | 1.8 | Low expression |
| MCF7 (breast cancer) | 4.5 | Moderate expression |
| A549 (lung cancer) | 3.2 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.154C>T (p.Arg52Cys) | Missense | <0.01% | Unknown functional effect; reported in ClinVar |
| c.487G>A (p.Gly163Ser) | Missense | <0.01% | Likely benign; no known disease association |
| c.832C>T (p.Arg278Trp) | Missense | <0.01% | Uncertain significance; not linked to specific phenotype |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in CMKLR1.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in CMKLR1.
Dominant Negative (DN)
No dominant-negative mutations described for CMKLR1.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity | • chemerin binding |
| • chemokine receptor activity | • cell chemotaxis |
| • positive regulation of cytosolic calcium ion concentration | • adipocyte differentiation |
| • inflammatory response |
Pathways
• Chemerin signaling pathway
• GPCR downstream signaling
• Adipogenesis
• Immune cell chemotaxis
Protein Summary
CMKLR1 (Chemokine Like Receptor 1) is a 371-amino acid G protein-coupled receptor with seven transmembrane domains. It is activated by chemerin (RARRES2), leading to intracellular calcium mobilization, MAPK/ERK activation, and PI3K/Akt signaling. The receptor is critical for dendritic cell and macrophage chemotaxis, adipocyte differentiation, and metabolic regulation. Altered expression or function is implicated in obesity, type 2 diabetes, inflammatory diseases, and cancer.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CMKLR1 Knockout HEK293 Cell Line | EDJ-KQ3253 | Human | 1240 | Details Get a Quote |
| CMKLR1 Knockout HeLa Cell Line | EDJ-KQ52938 | Human | 1240 | Details Get a Quote |
| CMKLR1 Knockout A-549 Cell Line | EDJ-KQ61405 | Human | 1240 | Details Get a Quote |
| CMKLR1 Knockout HCT 116 Cell Line | EDJ-KQ69900 | Human | 1240 | Details Get a Quote |
