CLPS (Colipase) Gene
Essential cofactor for pancreatic lipase-mediated dietary fat digestion
Gene Information Card
| Symbol | CLPS |
|---|---|
| Full Name | Colipase |
| Gene Type | protein-coding |
| Chromosomal Location | 6p21.1 |
| NCBI Gene ID | 1207 ncbi.nlm.nih.gov/gene/1207 |
| Ensembl ID | ENSG00000112210 |
| UniProt ID | P04118 |
| OMIM ID | 120105 |
| HGNC ID | 2074 |
| Aliases | COLIPASE, colipase, pancreatic |
Description
The CLPS gene encodes colipase, a small protein cofactor secreted by the pancreas. Colipase binds to pancreatic lipase in the intestinal lumen, stabilizing its active conformation and anchoring it to lipid-water interfaces, thereby enabling efficient hydrolysis of dietary triglycerides into monoglycerides and free fatty acids. This function is critical for normal fat absorption.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Pancreatic insufficiency | Deficient colipase reduces lipase activity, impairing fat digestion | ClinVar, OMIM |
| Congenital lipase deficiency | Mutations in CLPS may contribute to severe fat malabsorption | OMIM #246600 |
| Chronic pancreatitis | Altered colipase expression correlates with exocrine dysfunction | NCBI Gene, PubMed |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Pancreas | 1234.5 | High |
| Duodenum | 12.3 | Low |
| Liver | 1.2 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| PANC-1 (pancreatic) | 45.6 | Moderate expression |
| Capan-2 (pancreatic) | 38.9 | Moderate expression |
| HepG2 (liver) | 0.5 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | missense | <0.01% | Likely loss of start codon, reduced protein |
| c.205C>T (p.Arg69Cys) | missense | <0.01% | Impaired lipase binding |
| c.320delG | frameshift | <0.01% | Premature truncation, loss of function |
Mutation functional classification
Loss of Function (LOF)
Most reported CLPS mutations lead to reduced or absent colipase activity, impairing fat digestion.
Gain of Function (GOF)
No gain-of-function mutations documented.
Dominant Negative (DN)
No dominant-negative effects reported.
View complete mutation data：
Gene Ontology (GO)
| • lipase activator activity (GO:0016298) | • extracellular region (GO:0005576) |
| • lipid metabolic process (GO:0006629) | • homeostatic process (GO:0042592) |
Pathways
• REACT:1483201 – Digestion of dietary lipid
• WP:WP1760 – Pancreatic secretion pathway
Protein Summary
Colipase is a 10.5 kDa secreted protein composed of 112 amino acids. It contains three conserved disulfide bridges and a hydrophobic surface that interacts with lipid droplets. The protein binds pancreatic lipase with high affinity, enabling the lipase to overcome inhibition by bile salts and efficiently digest dietary triglycerides.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CLPSL2 Knockout HEK293 Cell Line | EDJ-KQ12192 | Human | 389383 | Details Get a Quote |
| CLPSL1 Knockout HEK293 Cell Line | EDJ-KQ12950 | Human | 340204 | Details Get a Quote |
| CLPS Knockout HEK293 Cell Line | EDJ-KQ50200 | Human | 1208 | Details Get a Quote |
| CLPS Knockout HeLa Cell Line | EDJ-KQ52928 | Human | 1208 | Details Get a Quote |
| CLPSL1 Knockout HeLa Cell Line | EDJ-KQ59670 | Human | 340204 | Details Get a Quote |
| CLPSL2 Knockout HeLa Cell Line | EDJ-KQ60082 | Human | 389383 | Details Get a Quote |
| CLPS Knockout A-549 Cell Line | EDJ-KQ61396 | Human | 1208 | Details Get a Quote |
| CLPSL1 Knockout A-549 Cell Line | EDJ-KQ68142 | Human | 340204 | Details Get a Quote |
| CLPSL2 Knockout A-549 Cell Line | EDJ-KQ68546 | Human | 389383 | Details Get a Quote |
| CLPS Knockout HCT 116 Cell Line | EDJ-KQ69891 | Human | 1208 | Details Get a Quote |
| CLPSL1 Knockout HCT 116 Cell Line | EDJ-KQ76519 | Human | 340204 | Details Get a Quote |
| CLPSL2 Knockout HCT 116 Cell Line | EDJ-KQ76921 | Human | 389383 | Details Get a Quote |
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