CLASP2: Cytoplasmic Linker Associated Protein 2
Microtubule Stabilizer and Cell Polarity Regulator
Gene Information Card
| Symbol | CLASP2 |
|---|---|
| Full Name | Cytoplasmic Linker Associated Protein 2 |
| Gene Type | Protein coding |
| Chromosomal Location | 3p22.3 |
| NCBI Gene ID | 23122 ncbi.nlm.nih.gov/gene/23122 |
| Ensembl ID | ENSG00000163534 |
| UniProt ID | Q75122 |
| OMIM ID | 609602 |
| HGNC ID | 24913 |
| Aliases | KIAA0627, CLIP-associating protein 2, CLASP2alpha, CLASP2beta |
Description
CLASP2 encodes a member of the CLASP family of microtubule-associated proteins that stabilize microtubules and regulate their dynamics. The protein localizes to the Golgi apparatus and kinetochores, playing a critical role in cell polarity, spindle orientation, and cell migration. CLASP2 interacts with CLIPs and EB1 to promote microtubule rescue and capture at the cell cortex.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | CLASP2 overexpression correlates with poor prognosis; promotes cell migration and invasion via microtubule stabilization | COSMIC, NCBI |
| Colorectal cancer | CLASP2 mutations found in tumor samples; altered expression linked to metastasis | COSMIC, ClinVar |
| Neurodevelopmental disorders | Rare variants in CLASP2 associated with intellectual disability and autism spectrum disorder | ClinVar, OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Lung | 8.3 | Low |
| Breast | 15.2 | Medium |
| Colon | 10.1 | Medium |
| Testis | 20.4 | High |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 (breast cancer) | 18.6 | Overexpressed compared to normal |
| HeLa (cervical cancer) | 14.2 | Moderate expression |
| A549 (lung cancer) | 9.8 | Low expression |
| HCT116 (colorectal cancer) | 16.3 | High expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T (p.Arg412Trp) | Missense | 0.02% | Alters microtubule binding affinity |
| c.567delA (p.Lys189fs) | Frameshift | <0.01% | Loss of function; truncated protein |
| c.2101G>A (p.Glu701Lys) | Missense | 0.05% | Potential gain-of-function in cancer |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense mutations lead to truncated protein lacking C-terminal microtubule-binding domain, impairing microtubule stabilization.
Gain of Function (GOF)
Missense mutations like p.Glu701Lys may enhance microtubule binding or alter localization, promoting cell migration in cancer.
Dominant Negative (DN)
Some missense variants may interfere with wild-type CLASP2 function by disrupting dimerization or interactions with CLIPs.
View complete mutation data：
Gene Ontology (GO)
| • microtubule binding | • microtubule cytoskeleton organization |
| • cell division | • cell migration |
| • Golgi organization | • kinetochore localization |
Pathways
• Microtubule dynamics regulation
• Cell cycle
• mitotic
• CLASP-mediated microtubule stabilization
• Golgi-to-cell cortex microtubule capture
Protein Summary
CLASP2 is a 1,539-amino acid protein with N-terminal TOG domains for tubulin binding and a C-terminal domain for interaction with CLIPs and EB1. It localizes to the Golgi apparatus and kinetochores, promoting microtubule rescue and capture. The protein is essential for asymmetric cell division, cell polarity, and directed cell migration. Alternative splicing generates isoforms with distinct functions.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CLASP2 Knockout HEK293 Cell Line | EDJ-KQ7838 | Human | 23122 | Details Get a Quote |
| CLASP2 Knockout A-549 Cell Line | EDJ-KQ33382 | Human | 23122 | Details Get a Quote |
| CLASP2 Knockout HCT 116 Cell Line | EDJ-KQ33383 | Human | 23122 | Details Get a Quote |
| CLASP2 Knockout HeLa Cell Line | EDJ-KQ33384 | Human | 23122 | Details Get a Quote |
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