CKLF-CMTM1 Gene Overview
CKLF-CMTM1 readthrough transcript: a unique fusion gene in the chemokine-like factor superfamily
Gene Information Card
| Symbol | CKLF-CMTM1 |
|---|---|
| Full Name | CKLF-CMTM1 readthrough (NMD candidate) |
| Gene Type | Readthrough transcript (protein-coding, NMD candidate) |
| Chromosomal Location | 16q21 |
| NCBI Gene ID | 100527951 ncbi.nlm.nih.gov/gene/100527951 |
| Ensembl ID | ENSG00000267508 |
| UniProt ID | Not available (NMD candidate) |
| OMIM ID | Not available |
| HGNC ID | HGNC:44277 |
| Aliases | CKLF-CMTM1 readthrough, CKLF-CMTM1 fusion |
Description
CKLF-CMTM1 is a readthrough transcript that spans the CKLF (chemokine-like factor) and CMTM1 (CKLF-like MARVEL transmembrane domain containing 1) genes on chromosome 16q21. This naturally occurring fusion transcript is predicted to undergo nonsense-mediated decay (NMD) and may not produce a stable protein. The individual CKLF and CMTM1 genes encode proteins involved in chemokine signaling and membrane trafficking, respectively. The readthrough transcript is primarily of interest in gene regulation and cancer genomics.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (general) | Potential dysregulation of CKLF/CMTM1 pathways; readthrough may affect transcript stability | Limited; inferred from individual gene associations (COSMIC, NCBI) |
| Inflammatory diseases | CKLF is a chemokine-like factor involved in inflammation; readthrough may alter expression | Inferred from CKLF function (UniProt, NCBI) |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 0.3 | Low |
| Bone marrow | 0.2 | Low |
| Lymph node | 0.1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| K562 (leukemia) | 0.1 | Low expression; NMD candidate |
| HeLa (cervical) | 0.0 | Not detected |
| HEK293 (embryonic kidney) | 0.0 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No specific variants curated | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No data; readthrough transcript is NMD candidate, likely not functional
Gain of Function (GOF)
No data
Dominant Negative (DN)
No data
View complete mutation data：
Gene Ontology (GO)
| • Not available (readthrough transcript, NMD candidate) |
Pathways
• Not available (readthrough transcript
• NMD candidate)
Protein Summary
The CKLF-CMTM1 readthrough transcript is predicted to undergo nonsense-mediated decay and is unlikely to produce a stable, functional protein. The individual CKLF and CMTM1 proteins are involved in chemokine signaling and membrane organization, respectively. No protein product has been experimentally confirmed for this fusion transcript.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CKLF-CMTM1 Knockout HEK293 Cell Line | EDJ-KQ52498 | Human | 100529251 | Details Get a Quote |
| CKLF-CMTM1 Knockout HeLa Cell Line | EDJ-KQ60961 | Human | 100529251 | Details Get a Quote |
| CKLF-CMTM1 Knockout A-549 Cell Line | EDJ-KQ69436 | Human | 100529251 | Details Get a Quote |
| CKLF-CMTM1 Knockout HCT 116 Cell Line | EDJ-KQ77787 | Human | 100529251 | Details Get a Quote |
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