CHST13: Carbohydrate Sulfotransferase 13
Gene encoding a sulfotransferase involved in proteoglycan modification and potential roles in cancer and development.
Gene Information Card
| Symbol | CHST13 |
|---|---|
| Full Name | Carbohydrate Sulfotransferase 13 |
| Gene Type | Protein coding |
| Chromosomal Location | 3q13.33 |
| NCBI Gene ID | 150166 ncbi.nlm.nih.gov/gene/150166 |
| Ensembl ID | ENSG00000163827 |
| UniProt ID | Q8NET6 |
| OMIM ID | 610124 |
| HGNC ID | 15957 |
| Aliases | C4ST3, chondroitin 4-sulfotransferase 3 |
Description
CHST13 encodes a member of the carbohydrate sulfotransferase family. The enzyme catalyzes the transfer of sulfate to position 4 of N-acetylgalactosamine residues in chondroitin, contributing to the biosynthesis of chondroitin sulfate proteoglycans. These proteoglycans are critical components of the extracellular matrix and are involved in cell signaling, adhesion, and migration. CHST13 expression is implicated in cancer progression and developmental processes.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal Cancer | Altered CHST13 expression may affect tumor cell adhesion and invasion via modification of chondroitin sulfate chains. | PubMed: 25691885 |
| Breast Cancer | Upregulation of CHST13 is associated with poor prognosis and may promote metastasis through proteoglycan remodeling. | PubMed: 29187736 |
| Osteoarthritis | Potential role in cartilage matrix degradation due to altered sulfation patterns of chondroitin sulfate. | PubMed: 20628086 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 5.2 | Low |
| Colon | 12.8 | Medium |
| Breast | 8.4 | Low |
| Liver | 3.1 | Low |
| Lung | 6.7 | Low |
| Kidney | 4.5 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 9.3 | Cervical cancer cell line |
| MCF7 | 11.5 | Breast cancer cell line |
| HCT116 | 14.2 | Colorectal cancer cell line |
| A549 | 7.8 | Lung cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.374C>T (p.Thr125Met) | Missense | <0.01% | Unknown functional impact |
| c.523G>A (p.Gly175Ser) | Missense | <0.01% | Predicted benign by in silico tools |
| c.788A>G (p.Asn263Ser) | Missense | <0.01% | No known disease association |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in CHST13.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in CHST13.
Dominant Negative (DN)
No evidence of dominant-negative effects for CHST13 mutations.
View complete mutation data：
Gene Ontology (GO)
| • N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity (GO:0001517) | • N-acetylglucosamine metabolic process (GO:0006044) |
| • sulfur compound metabolic process (GO:0006790) | • heparan sulfate proteoglycan biosynthetic process (GO:0015014) |
| • chondroitin sulfate proteoglycan biosynthetic process (GO:0015015) | • glycosaminoglycan metabolic process (GO:0030203) |
Pathways
• Chondroitin sulfate/dermatan sulfate biosynthesis (Reactome: R-HSA-1971475)
• Glycosaminoglycan metabolism (KEGG: hsa00532)
Protein Summary
CHST13 encodes a 395-amino acid type II transmembrane protein localized to the Golgi apparatus. It functions as a sulfotransferase that transfers sulfate from 3'-phosphoadenosine-5'-phosphosulfate (PAPS) to position 4 of N-acetylgalactosamine residues in chondroitin. This modification is essential for the proper assembly and function of chondroitin sulfate proteoglycans, which modulate cell signaling, extracellular matrix organization, and cell adhesion. The protein is expressed in various tissues, with highest levels in colon and breast. Altered expression is observed in several cancers, suggesting a role in tumor progression.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CHST13 Knockout HEK293 Cell Line | EDJ-KQ12921 | Human | 166012 | Details Get a Quote |
| CHST13 Knockout HeLa Cell Line | EDJ-KQ42128 | Human | 166012 | Details Get a Quote |
| CHST13 Knockout A-549 Cell Line | EDJ-KQ67384 | Human | 166012 | Details Get a Quote |
| CHST13 Knockout HCT 116 Cell Line | EDJ-KQ75776 | Human | 166012 | Details Get a Quote |
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