CHST11: Carbohydrate Sulfotransferase 11
Key enzyme in chondroitin sulfate biosynthesis and its role in development and disease
Gene Information Card
| Symbol | CHST11 |
|---|---|
| Full Name | Carbohydrate Sulfotransferase 11 |
| Gene Type | Protein coding |
| Chromosomal Location | 12q23.3 |
| NCBI Gene ID | 50515 ncbi.nlm.nih.gov/gene/50515 |
| Ensembl ID | ENSG00000171310 |
| UniProt ID | Q9NPF2 |
| OMIM ID | 610191 |
| HGNC ID | 19223 |
| Aliases | C4ST1, C4ST-1, HSA269257 |
Description
CHST11 encodes a member of the sulfotransferase family that catalyzes the transfer of sulfate to position 4 of N-acetylgalactosamine residues in chondroitin sulfate. This enzyme is critical for the biosynthesis of chondroitin sulfate, a major component of the extracellular matrix involved in cell signaling, development, and tissue homeostasis. CHST11 is expressed in various tissues and is implicated in skeletal development, cancer progression, and inflammatory responses.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Altered chondroitin sulfate sulfation patterns may promote tumor growth and metastasis | COSMIC; PMID: 23542377 |
| Osteoarthritis | Dysregulation of chondroitin sulfate sulfation in cartilage contributes to joint degeneration | NCBI Gene; PMID: 20037587 |
| Skeletal dysplasia | Mutations in CHST11 disrupt chondroitin sulfate biosynthesis, affecting bone development | OMIM #610191; PMID: 20037587 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Heart | 8.3 | Low |
| Liver | 4.1 | Low |
| Lung | 15.2 | Medium |
| Kidney | 9.7 | Low |
| Skeletal muscle | 6.8 | Low |
| Placenta | 18.9 | Medium |
| Testis | 22.1 | High |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 14.5 | Cervical cancer cell line |
| A549 | 11.2 | Lung cancer cell line |
| MCF7 | 9.8 | Breast cancer cell line |
| HEK293 | 16.3 | Embryonic kidney cell line |
| K562 | 7.4 | Leukemia cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.100C>T (p.Arg34Trp) | Missense | <0.01% | Reduced enzyme activity; associated with skeletal dysplasia |
| c.487G>A (p.Gly163Arg) | Missense | <0.01% | Loss of function; reported in OMIM |
| c.763_764insA | Frameshift | <0.01% | Truncated protein; likely loss of function |
Mutation functional classification
Loss of Function (LOF)
Missense and frameshift mutations reduce or abolish sulfotransferase activity, impairing chondroitin sulfate biosynthesis.
Gain of Function (GOF)
No gain-of-function mutations reported in CHST11.
Dominant Negative (DN)
No dominant-negative mutations reported in CHST11.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Chondroitin sulfate/dermatan sulfate biosynthesis (Reactome: R-HSA-1793185)
• Glycosaminoglycan metabolism (KEGG: hsa00532)
• Sulfation of glycosaminoglycans (Reactome: R-HSA-1638091)
Protein Summary
CHST11 (C4ST1) is a 411-amino acid type II transmembrane protein localized to the Golgi apparatus. It catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 4 of N-acetylgalactosamine residues in chondroitin sulfate. This sulfation step is essential for the formation of chondroitin sulfate chains, which modulate cell adhesion, migration, and signaling. The protein contains a sulfotransferase domain and is expressed in multiple tissues, with highest levels in testis and placenta.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CHST11 Knockout HEK293 Cell Line | EDJ-KQ10766 | Human | 50515 | Details Get a Quote |
| CHST11 Knockout A-549 Cell Line | EDJ-KQ38375 | Human | 50515 | Details Get a Quote |
| CHST11 Knockout HCT 116 Cell Line | EDJ-KQ38376 | Human | 50515 | Details Get a Quote |
| CHST11 Knockout HeLa Cell Line | EDJ-KQ38377 | Human | 50515 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
