CEBPG: CCAAT Enhancer Binding Protein Gamma
A key transcriptional regulator in hematopoiesis, immune response, and cancer
Gene Information Card
| Symbol | CEBPG |
|---|---|
| Full Name | CCAAT enhancer binding protein gamma |
| Gene Type | protein-coding |
| Chromosomal Location | 19q13.11 |
| NCBI Gene ID | 1054 ncbi.nlm.nih.gov/gene/1054 |
| Ensembl ID | ENSG00000105679 |
| UniProt ID | P53567 |
| OMIM ID | 116897 |
| HGNC ID | 2426 |
| Aliases | GPE1BP, C/EBP-gamma, CEBPG1 |
Description
CEBPG encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein forms heterodimers with other C/EBP family members (e.g., CEBPA, CEBPB) and regulates genes involved in immune and inflammatory responses, hematopoiesis, and cell differentiation. CEBPG is widely expressed and plays a role in myeloid and lymphoid development, as well as in cancer progression.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Acute Myeloid Leukemia | CEBPG mutations may disrupt normal myeloid differentiation by altering C/EBP heterodimer formation | COSMIC, ClinVar |
| Chronic Lymphocytic Leukemia | CEBPG overexpression or mutation contributes to B-cell survival and proliferation | COSMIC |
| Breast Cancer | CEBPG dysregulation influences epithelial-mesenchymal transition and metastasis | NCBI Gene, COSMIC |
| Inflammatory Bowel Disease | CEBPG regulates cytokine expression in intestinal inflammation | OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Bone Marrow | 15.2 | High |
| Lymph Node | 12.8 | High |
| Spleen | 11.5 | High |
| Lung | 8.3 | Medium |
| Liver | 6.1 | Medium |
| Brain | 2.4 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| K562 (leukemia) | 18.7 | High expression; model for myeloid differentiation |
| HL-60 (promyeloblast) | 16.3 | High expression; role in granulopoiesis |
| MCF7 (breast cancer) | 9.2 | Moderate expression; associated with EMT |
| HEK293 (embryonic kidney) | 5.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.437C>T (p.Pro146Leu) | Missense | 0.02% (COSMIC) | May alter DNA-binding affinity |
| c.523_524insA (p.Thr175Asnfs*12) | Frameshift | 0.01% (COSMIC) | Loss of function; truncated protein |
| c.689G>A (p.Arg230Gln) | Missense | 0.03% (ClinVar) | Uncertain significance; reported in AML |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense mutations that truncate the bZIP domain impair DNA binding and heterodimerization, leading to loss of transcriptional activity.
Gain of Function (GOF)
Missense mutations in the transactivation domain may enhance CEBPG stability or interaction with coactivators, though evidence is limited.
Dominant Negative (DN)
Mutations that produce truncated proteins capable of dimerizing with wild-type C/EBP factors but unable to bind DNA can act in a dominant-negative manner.
View complete mutation data：
Gene Ontology (GO)
Pathways
• IL-6 signaling pathway (Reactome: R-HSA-1059683)
• C/EBP transcription factor network (KEGG: hsa04630)
• Myeloid cell differentiation (WikiPathways: WP2841)
Protein Summary
CEBPG is a 150-amino-acid transcription factor containing a basic leucine zipper (bZIP) domain. It lacks a transactivation domain and functions primarily as a heterodimeric partner for other C/EBP proteins. Through dimerization, it modulates the expression of genes involved in inflammation, hematopoiesis, and cell cycle control. Post-translational modifications such as phosphorylation regulate its activity and stability.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CEBPG Knockout HEK293 Cell Line | EDJ-KQ3554 | Human | 1054 | Details Get a Quote |
| CEBPG Knockout A-549 Cell Line | EDJ-KQ26723 | Human | 1054 | Details Get a Quote |
| CEBPG Knockout HCT 116 Cell Line | EDJ-KQ26725 | Human | 1054 | Details Get a Quote |
| CEBPG Knockout HeLa Cell Line | EDJ-KQ26726 | Human | 1054 | Details Get a Quote |
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