CEACAM6 (Carcinoembryonic Antigen Related Cell Adhesion Molecule 6)
A GPI-anchored glycoprotein involved in cell adhesion, immune modulation, and tumor progression.
Gene Information Card
| Symbol | CEACAM6 |
|---|---|
| Full Name | Carcinoembryonic Antigen Related Cell Adhesion Molecule 6 |
| Gene Type | protein-coding |
| Chromosomal Location | 19q13.2 |
| NCBI Gene ID | 4680 ncbi.nlm.nih.gov/gene/4680 |
| Ensembl ID | ENSG00000105338 |
| UniProt ID | P40199 |
| OMIM ID | 163980 |
| HGNC ID | 1819 |
| Aliases | CD66c, CEAL, NCA |
Description
CEACAM6 (Carcinoembryonic Antigen Related Cell Adhesion Molecule 6) is a member of the carcinoembryonic antigen (CEA) family. It encodes a glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein that mediates homophilic and heterophilic cell adhesion. CEACAM6 is overexpressed in various cancers, including pancreatic, colorectal, and gastric adenocarcinomas, and contributes to tumor progression, invasion, and resistance to anoikis. It also modulates immune responses by interacting with receptors on neutrophils and T cells.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Pancreatic adenocarcinoma | Overexpression promotes invasion and metastasis; inhibits anoikis | PMID: 15604206; COSMIC |
| Colorectal carcinoma | Upregulation correlates with poor prognosis and chemoresistance | PMID: 11839816; ClinVar |
| Gastric cancer | High expression associated with lymph node metastasis | PMID: 21532985 |
| Breast cancer | Aberrant expression linked to aggressive subtypes | PMID: 22952190 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Colon | 12.5 | Medium |
| Pancreas | 8.3 | Medium |
| Stomach | 6.1 | Low |
| Lung | 4.7 | Low |
| Liver | 1.2 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| BxPC-3 (pancreatic) | 15.2 | High expression |
| HT-29 (colorectal) | 11.8 | High expression |
| MCF-7 (breast) | 3.4 | Low expression |
| HEK293 (embryonic kidney) | 0.5 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | missense | <0.1% (COSMIC) | Likely loss of start codon; functional impact unknown |
| c.487G>A (p.Gly163Arg) | missense | <0.1% (COSMIC) | Rare; no known pathogenic effect |
| c.1024C>T (p.Arg342Trp) | missense | <0.1% (COSMIC) | Rare; no known pathogenic effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in COSMIC or ClinVar.
Gain of Function (GOF)
Overexpression (not mutation) is the primary gain-of-function mechanism in cancers.
Dominant Negative (DN)
Not described for CEACAM6.
View complete mutation data：
Gene Ontology (GO)
| • cell adhesion (GO:0007155) | • plasma membrane (GO:0005886) |
| • anchored component of membrane (GO:0031225) | • protein binding (GO:0005515) |
| • receptor complex (GO:0043235) |
Pathways
• Cell adhesion molecules (CAMs) – KEGG hsa04514
• Hematopoietic cell lineage – KEGG hsa04640
Protein Summary
CEACAM6 is a 344-amino acid GPI-anchored glycoprotein (UniProt P40199) with an N-terminal immunoglobulin-like domain and two C2-set domains. It localizes to the apical surface of epithelial cells and mediates homophilic adhesion. In cancer, overexpression disrupts cell polarity, enhances invasion, and protects cells from apoptosis. It is also a target for antibody-based therapies.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CEACAM6 Knockout HEK293 Cell Line | EDJ-KQ50464 | Human | 4680 | Details Get a Quote |
| CEACAM6 Knockout HeLa Cell Line | EDJ-KQ53963 | Human | 4680 | Details Get a Quote |
| CEACAM6 Knockout A-549 Cell Line | EDJ-KQ62452 | Human | 4680 | Details Get a Quote |
| CEACAM6 Knockout HCT 116 Cell Line | EDJ-KQ70918 | Human | 4680 | Details Get a Quote |
