CDK20: Cyclin Dependent Kinase 20
A cell cycle regulator and potential oncogene in hepatocellular carcinoma
Gene Information Card
| Symbol | CDK20 |
|---|---|
| Full Name | Cyclin Dependent Kinase 20 |
| Gene Type | Protein coding |
| Chromosomal Location | 9q22.1 |
| NCBI Gene ID | 23552 ncbi.nlm.nih.gov/gene/23552 |
| Ensembl ID | ENSG00000107104 |
| UniProt ID | Q8IZL9 |
| OMIM ID | 611447 |
| HGNC ID | 20287 |
| Aliases | CCRK, P42, bA864N19.2, cell cycle related kinase |
Description
CDK20 (Cyclin Dependent Kinase 20), also known as CCRK (Cell Cycle Related Kinase), is a protein-coding gene that encodes a member of the cyclin-dependent kinase family. The protein is involved in cell cycle regulation, particularly in the G1/S transition, and has been implicated in ciliary function and hepatocellular carcinoma progression. CDK20 interacts with cyclin H and CDK7 to activate CDK2, and is also required for proper ciliogenesis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Hepatocellular carcinoma | CDK20 overexpression promotes cell proliferation and tumor growth via activation of CDK2 and Rb phosphorylation | PMID: 20010866 |
| Orofacial cleft 12 | Homozygous missense variant in CDK20 associated with cleft lip/palate | PMID: 28132692 |
| Primary microcephaly | Loss-of-function mutations in CDK20 impair centriole duplication and cause microcephaly | PMID: 28132692 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Liver | 6.8 | Low |
| Brain | 4.2 | Low |
| Kidney | 3.9 | Low |
| Heart | 2.1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 8.5 | Hepatocellular carcinoma cell line |
| HEK293 | 6.2 | Embryonic kidney cells |
| HeLa | 5.0 | Cervical cancer cells |
| A549 | 4.1 | Lung carcinoma cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.832C>T (p.Arg278Cys) | Missense | Rare | Loss of function; associated with orofacial cleft and microcephaly |
| c.1A>G (p.Met1Val) | Start loss | Rare | Loss of function; associated with primary microcephaly |
| c.715G>A (p.Gly239Arg) | Missense | Rare | Likely damaging; reported in ClinVar |
Mutation functional classification
Loss of Function (LOF)
Missense and start-loss mutations in CDK20 impair kinase activity and centriole duplication, leading to microcephaly and orofacial clefts.
Gain of Function (GOF)
Overexpression of wild-type CDK20 in hepatocellular carcinoma acts as an oncogene by promoting cell cycle progression.
Dominant Negative (DN)
Not reported for CDK20.
View complete mutation data：
Gene Ontology (GO)
| • cyclin-dependent protein serine/threonine kinase activity (GO:0004693) | • protein binding (GO:0005515) |
| • protein phosphorylation (GO:0006468) | • cell cycle (GO:0007049) |
| • phosphorylation (GO:0016310) | • cell projection organization (GO:0030030) |
| • cilium assembly (GO:0042384) |
Pathways
• Cell Cycle (KEGG: hsa04110)
• Cilium Assembly (Reactome: R-HSA-5620912)
• CDK-mediated phosphorylation and removal of Cdc6 (Reactome: R-HSA-69017)
Protein Summary
CDK20 encodes a 42 kDa serine/threonine protein kinase (UniProt Q8IZL9) that localizes to the nucleus and centrosome. It contains a typical kinase domain and is essential for cell cycle progression through G1/S transition. CDK20 forms a complex with cyclin H and CDK7 to phosphorylate and activate CDK2. Additionally, it plays a critical role in ciliogenesis by regulating centriole duplication. Mutations in CDK20 cause autosomal recessive primary microcephaly and orofacial clefting, while overexpression is oncogenic in hepatocellular carcinoma.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CDK20 Knockout HEK293 Cell Line | EDJ-KQ8070 | Human | 23552 | Details Get a Quote |
| CDK20 Knockout A-549 Cell Line | EDJ-KQ32559 | Human | 23552 | Details Get a Quote |
| CDK20 Knockout HCT 116 Cell Line | EDJ-KQ33900 | Human | 23552 | Details Get a Quote |
| CDK20 Knockout HeLa Cell Line | EDJ-KQ33901 | Human | 23552 | Details Get a Quote |
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