CDH26 (Cadherin 26)
A non-classical cadherin involved in cell adhesion, immune regulation, and potential tumor suppression.
Gene Information Card
| Symbol | CDH26 |
|---|---|
| Full Name | Cadherin 26 |
| Gene Type | Protein-coding |
| Chromosomal Location | 20q13.33 |
| NCBI Gene ID | 60437 ncbi.nlm.nih.gov/gene/60437 |
| Ensembl ID | ENSG00000124215 |
| UniProt ID | Q8IXH8 |
| OMIM ID | 609122 |
| HGNC ID | 14272 |
| Aliases | CDH27, cadherin-like 26, VR20 |
Description
CDH26 (Cadherin 26) encodes a non-classical cadherin that lacks the typical HAV cell adhesion recognition motif. It is involved in calcium-dependent cell-cell adhesion, immune modulation, and epithelial barrier function. CDH26 is expressed in the respiratory and gastrointestinal tracts and has been implicated in asthma, allergic inflammation, and various cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Asthma | CDH26 variants may alter airway epithelial integrity and immune response, contributing to asthma susceptibility. | ClinVar, OMIM |
| Allergic rhinitis | Polymorphisms in CDH26 are associated with increased risk of allergic rhinitis in genome-wide studies. | NCBI Gene, OMIM |
| Colorectal cancer | Reduced CDH26 expression is observed in colorectal tumors, suggesting a tumor-suppressive role through loss of cell adhesion. | COSMIC, NCBI Gene |
| Ovarian cancer | CDH26 hypermethylation and downregulation are linked to ovarian cancer progression and metastasis. | COSMIC, PubMed |
| Inflammatory bowel disease | CDH26 expression is altered in intestinal epithelium of IBD patients, potentially affecting barrier function. | NCBI Gene |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 12.5 | Medium |
| Small intestine | 18.3 | High |
| Colon | 15.7 | High |
| Stomach | 9.2 | Medium |
| Trachea | 11.0 | Medium |
| Esophagus | 7.8 | Low |
| Kidney | 3.4 | Low |
| Liver | 1.2 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| A549 (lung carcinoma) | 8.5 | Moderate expression |
| Caco-2 (colorectal adenocarcinoma) | 14.2 | High expression |
| HCT116 (colorectal carcinoma) | 6.1 | Low expression |
| HeLa (cervical adenocarcinoma) | 2.3 | Very low |
| MCF7 (breast adenocarcinoma) | 1.1 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1045C>T (p.Arg349Trp) | Missense | 0.0004 (gnomAD) | Unknown; predicted damaging by SIFT |
| c.1876G>A (p.Val626Met) | Missense | 0.0002 (gnomAD) | Unknown; likely benign |
| c.2345_2346insA | Frameshift | <0.0001 | Loss of function |
| c.3010C>T (p.Arg1004*) | Nonsense | <0.0001 | Loss of function; truncation |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense mutations (e.g., c.2345_2346insA, c.3010C>T) are predicted to cause loss of function through protein truncation or nonsense-mediated decay.
Gain of Function (GOF)
No gain-of-function mutations have been reported for CDH26.
Dominant Negative (DN)
No dominant-negative mutations have been characterized for CDH26.
View complete mutation data：
Gene Ontology (GO)
| • homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156) | • calcium ion binding (GO:0005509) |
| • membrane (GO:0016020) | • plasma membrane (GO:0005886) |
| • cell-cell adherens junction (GO:0005913) | • cell-cell adhesion (GO:0098609) |
Pathways
• Cell adhesion molecules (CAMs) – KEGG hsa04514
• Adherens junction – KEGG hsa04520
• Wnt signaling pathway (indirect via β-catenin interaction)
Protein Summary
Cadherin 26 is a 1004-amino acid transmembrane glycoprotein belonging to the cadherin superfamily. It contains five extracellular cadherin repeats, a transmembrane domain, and a cytoplasmic tail. Unlike classical cadherins, CDH26 lacks the HAV motif and may mediate calcium-dependent adhesion through alternative mechanisms. The protein is expressed in epithelial tissues, particularly in the lung and gastrointestinal tract, and plays roles in maintaining barrier integrity and immune homeostasis. Altered expression or mutation of CDH26 is associated with asthma, allergic diseases, and epithelial cancers.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CDH26 Knockout HEK293 Cell Line | EDJ-KQ980 | Human | 60437 | Details Get a Quote |
| CDH26 Knockout HeLa Cell Line | EDJ-KQ56976 | Human | 60437 | Details Get a Quote |
| CDH26 Knockout A-549 Cell Line | EDJ-KQ65478 | Human | 60437 | Details Get a Quote |
| CDH26 Knockout HCT 116 Cell Line | EDJ-KQ73918 | Human | 60437 | Details Get a Quote |
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