CDH24 Gene - Cadherin 24
Comprehensive gene information for CDH24, a member of the cadherin superfamily involved in cell adhesion and potential tumor suppression.
Gene Information Card
| Symbol | CDH24 |
|---|---|
| Full Name | Cadherin 24 |
| Gene Type | Protein coding |
| Chromosomal Location | 14q11.2 |
| NCBI Gene ID | 64403 ncbi.nlm.nih.gov/gene/64403 |
| Ensembl ID | ENSG00000100823 |
| UniProt ID | Q86UP0 |
| OMIM ID | 605182 |
| HGNC ID | 1765 |
| Aliases | CDH11L, FLJ20160, MGC138207 |
Description
CDH24 (Cadherin 24) is a protein-coding gene belonging to the cadherin superfamily, which encodes calcium-dependent cell adhesion proteins. CDH24 is involved in cell-cell adhesion and may play a role in tumor suppression. It is located on chromosome 14q11.2 and is expressed in various tissues, with notable expression in the brain and testis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Potential tumor suppressor; loss of expression may promote metastasis | COSMIC; NCBI Gene |
| Colorectal cancer | Downregulation associated with poor prognosis | COSMIC; NCBI Gene |
| Gastric cancer | Reduced expression linked to tumor progression | COSMIC; NCBI Gene |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Testis | 8.3 | Medium |
| Lung | 4.1 | Low |
| Liver | 2.0 | Low |
| Kidney | 3.5 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 15.2 | High expression in embryonic kidney cells |
| HeLa | 6.8 | Moderate expression in cervical cancer cells |
| MCF7 | 2.1 | Low expression in breast cancer cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.101C>T (p.Thr34Met) | Missense | 0.01% (gnomAD) | Unknown functional impact |
| c.457G>A (p.Gly153Ser) | Missense | 0.005% (gnomAD) | Potential loss of adhesion |
| c.1234delC (p.Leu412Trpfs*5) | Frameshift | Rare | Loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense mutations likely lead to truncated protein and loss of cell adhesion function.
Gain of Function (GOF)
No known gain-of-function mutations reported.
Dominant Negative (DN)
Not documented for CDH24.
View complete mutation data：
Gene Ontology (GO)
| • homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156) | • calcium ion binding (GO:0005509) |
| • membrane (GO:0016020) | • plasma membrane (GO:0005886) |
Pathways
• Cell adhesion molecules (CAMs) - Homo sapiens (human)
• Adherens junction
Protein Summary
The CDH24 protein is a classical cadherin with extracellular cadherin repeats, a transmembrane domain, and a cytoplasmic tail. It mediates calcium-dependent cell-cell adhesion and is implicated in maintaining tissue integrity. Reduced expression is observed in several cancers, suggesting a tumor-suppressive role.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CDH24 Knockout HEK293 Cell Line | EDJ-KQ12840 | Human | 64403 | Details Get a Quote |
| CDH24 Knockout A-549 Cell Line | EDJ-KQ41989 | Human | 64403 | Details Get a Quote |
| CDH24 Knockout HCT 116 Cell Line | EDJ-KQ41990 | Human | 64403 | Details Get a Quote |
| CDH24 Knockout HeLa Cell Line | EDJ-KQ41991 | Human | 64403 | Details Get a Quote |
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