CDH13: Cadherin 13 (T-Cadherin) Gene
A comprehensive biomedical overview of CDH13, encoding T-cadherin, with roles in cell adhesion, cancer, and cardiovascular disease.
Gene Information Card
| Symbol | CDH13 |
|---|---|
| Full Name | Cadherin 13 |
| Gene Type | Protein coding |
| Chromosomal Location | 16q23.3 |
| NCBI Gene ID | 1012 ncbi.nlm.nih.gov/gene/1012 |
| Ensembl ID | ENSG00000140945 |
| UniProt ID | P55290 |
| OMIM ID | 601364 |
| HGNC ID | 1753 |
| Aliases | T-cadherin, H-cadherin, CDHH, P105 |
Description
CDH13 encodes T-cadherin, a member of the cadherin superfamily of calcium-dependent cell adhesion molecules. Unlike classical cadherins, T-cadherin lacks a transmembrane domain and is anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) moiety. It is involved in cell-cell adhesion, signaling, and modulation of cell growth. CDH13 is frequently silenced by promoter methylation in various cancers and is associated with cardiovascular traits such as hypertension and coronary artery disease.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Promoter hypermethylation silences CDH13 expression, reducing tumor suppression and promoting invasion. | ClinVar, COSMIC |
| Lung cancer | Loss of CDH13 expression via methylation correlates with poor prognosis and metastasis. | NCBI Gene, COSMIC |
| Coronary artery disease | Genetic variants in CDH13 are associated with altered plasma adiponectin levels and increased CAD risk. | OMIM, ClinVar |
| Hypertension | CDH13 polymorphisms linked to blood pressure regulation through adiponectin signaling. | OMIM |
| Colorectal cancer | CDH13 methylation detected in tumor tissues; associated with microsatellite instability. | COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Heart | 12.5 | Medium |
| Brain | 8.3 | Low |
| Lung | 15.2 | Medium |
| Liver | 2.1 | Not detected |
| Kidney | 9.8 | Low |
| Skeletal muscle | 6.4 | Low |
| Adipose tissue | 18.7 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 (breast cancer) | 5.2 | Low expression; often methylated |
| A549 (lung cancer) | 3.8 | Reduced due to promoter methylation |
| HUVEC (endothelial) | 22.1 | High expression; vascular role |
| HEK293 (embryonic kidney) | 14.5 | Moderate expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.748C>T (p.Arg250*) | Nonsense | <0.1% | Loss of function; truncated protein |
| c.1012G>A (p.Gly338Arg) | Missense | <0.1% | Unknown significance |
| Promoter methylation | Epigenetic | Common in tumors | Silencing of gene expression |
Mutation functional classification
Loss of Function (LOF)
Nonsense mutations (e.g., p.Arg250*) and promoter methylation lead to loss of T-cadherin expression, reducing cell adhesion and promoting tumor progression.
Gain of Function (GOF)
No well-characterized gain-of-function mutations reported in CDH13.
Dominant Negative (DN)
No dominant-negative mutations described for CDH13.
View complete mutation data：
Gene Ontology (GO)
| • homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156) | • calcium ion binding (GO:0005509) |
| • plasma membrane (GO:0005886) | • integral component of membrane (GO:0016021) |
| • signal transduction (GO:0007165) | • positive regulation of cell population proliferation (GO:0008284) |
Pathways
• Cell adhesion molecules (CAMs) – KEGG hsa04514
• Adipocytokine signaling pathway – KEGG hsa04920
• Regulation of actin cytoskeleton – KEGG hsa04810
Protein Summary
T-cadherin (UniProt P55290) is a 713-amino-acid GPI-anchored cadherin that mediates calcium-dependent cell adhesion and signaling. It is expressed in endothelial cells, smooth muscle, and neural tissues. The protein lacks a cytoplasmic domain and is involved in modulating cell growth, migration, and survival. Altered expression is linked to cancer and cardiovascular diseases.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CDH13 Knockout HEK293 Cell Line | EDJ-KQ4242 | Human | 1012 | Details Get a Quote |
| CDH13 Knockout HeLa Cell Line | EDJ-KQ26713 | Human | 1012 | Details Get a Quote |
| CDH13 Knockout A-549 Cell Line | EDJ-KQ61326 | Human | 1012 | Details Get a Quote |
| CDH13 Knockout HCT 116 Cell Line | EDJ-KQ69824 | Human | 1012 | Details Get a Quote |
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