CDH10 (Cadherin 10) Gene: Structure, Function, and Disease Associations
Comprehensive biomedical overview of the CDH10 gene, including genomic context, expression, mutations, and clinical relevance.
Gene Information Card
| Symbol | CDH10 |
|---|---|
| Full Name | cadherin 10 |
| Gene Type | protein-coding |
| Chromosomal Location | 5p14.2-p14.1 |
| NCBI Gene ID | 1008 ncbi.nlm.nih.gov/gene/1008 |
| Ensembl ID | ENSG00000145632 |
| UniProt ID | Q9Y6N8 |
| OMIM ID | 604555 |
| HGNC ID | 1750 |
| Aliases | cadherin-10, T2-cadherin |
Description
CDH10 (cadherin 10) is a protein-coding gene located on chromosome 5p14.2-p14.1. It encodes a type II classical cadherin, a calcium-dependent cell adhesion glycoprotein. Cadherins mediate homophilic cell-cell adhesion and are critical for tissue morphogenesis, maintenance of epithelial integrity, and neural development. CDH10 is predominantly expressed in the brain and is implicated in neurodevelopmental disorders and certain cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Autism spectrum disorder | Genetic association studies have linked CDH10 variants to ASD risk, possibly through altered neuronal adhesion and synaptic function. | PMID: 19118814; NCBI GeneRIF |
| Schizophrenia | CDH10 polymorphisms have been associated with schizophrenia in genome-wide association studies, suggesting a role in neurodevelopment. | PMID: 21926972; NCBI GeneRIF |
| Colorectal cancer | CDH10 promoter hypermethylation and reduced expression are observed in colorectal cancer, potentially contributing to tumor progression. | PMID: 23149706; COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 28.5 | High |
| Testis | 6.2 | Low |
| Lung | 2.1 | Not detected |
| Liver | 0.8 | Not detected |
| Kidney | 1.5 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| SH-SY5Y (neuroblastoma) | 35.2 | High expression; neuronal origin |
| U-87 MG (glioblastoma) | 22.8 | Moderate expression |
| HeLa (cervical carcinoma) | 0.5 | Very low expression |
| A549 (lung carcinoma) | 1.2 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1253G>A (p.Arg418Gln) | Missense | 0.01% (gnomAD) | Substitution in extracellular cadherin domain; potential impact on adhesion |
| c.1876C>T (p.Arg626Trp) | Missense | 0.005% (gnomAD) | Located in cytoplasmic domain; functional significance unknown |
| c.234delC (p.Pro79fs) | Frameshift | Rare | Predicted loss-of-function; may reduce protein expression |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense variants (e.g., c.234delC) are predicted to cause loss of function through nonsense-mediated decay or truncated protein.
Gain of Function (GOF)
No gain-of-function mutations have been reported for CDH10 in the literature or curated databases.
Dominant Negative (DN)
No dominant-negative mutations have been characterized for CDH10.
View complete mutation data：
Gene Ontology (GO)
| • homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156) | • calcium ion binding (GO:0005509) |
| • membrane (GO:0016020) | • plasma membrane (GO:0005886) |
| • cell-cell adherens junction (GO:0005913) |
Pathways
• Cell adhesion molecules (CAMs) – KEGG hsa04514
• Adherens junction – KEGG hsa04520
Protein Summary
Cadherin 10 is a 788-amino acid type II classical cadherin. It contains an N-terminal signal peptide, five extracellular cadherin repeats, a transmembrane domain, and a cytoplasmic tail. The extracellular domain mediates calcium-dependent homophilic adhesion, while the cytoplasmic domain interacts with catenins to link to the actin cytoskeleton. The protein is heavily glycosylated and plays roles in neural circuit formation and tissue integrity.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CDH10 Knockout HEK293 Cell Line | EDJ-KQ4239 | Human | 1008 | Details Get a Quote |
| PCDH10 Knockout HEK293 Cell Line | EDJ-KQ14699 | Human | 57575 | Details Get a Quote |
| CDH10 Knockout HeLa Cell Line | EDJ-KQ52858 | Human | 1008 | Details Get a Quote |
| PCDH10 Knockout HeLa Cell Line | EDJ-KQ56871 | Human | 57575 | Details Get a Quote |
| CDH10 Knockout A-549 Cell Line | EDJ-KQ61323 | Human | 1008 | Details Get a Quote |
| PCDH10 Knockout A-549 Cell Line | EDJ-KQ65385 | Human | 57575 | Details Get a Quote |
| CDH10 Knockout HCT 116 Cell Line | EDJ-KQ69821 | Human | 1008 | Details Get a Quote |
| PCDH10 Knockout HCT 116 Cell Line | EDJ-KQ73822 | Human | 57575 | Details Get a Quote |
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