CDCA4: Cell Division Cycle Associated 4
A regulator of cell cycle progression and transcription, implicated in cancer and developmental processes.
Gene Information Card
| Symbol | CDCA4 |
|---|---|
| Full Name | Cell Division Cycle Associated 4 |
| Gene Type | Protein coding |
| Chromosomal Location | 14q32.33 |
| NCBI Gene ID | 55038 ncbi.nlm.nih.gov/gene/55038 |
| Ensembl ID | ENSG00000100823 |
| UniProt ID | Q9BRT8 |
| OMIM ID | 609977 |
| HGNC ID | 14623 |
| Aliases | SEP3, HEPP |
Description
CDCA4 (Cell Division Cycle Associated 4) is a protein-coding gene located on chromosome 14q32.33. It encodes a transcription factor involved in cell cycle regulation, particularly during G1/S transition. CDCA4 interacts with E2F transcription factors and is implicated in cellular proliferation, differentiation, and apoptosis. Overexpression has been observed in various cancers, suggesting a role in oncogenesis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Overexpression of CDCA4 promotes cell proliferation and tumor growth; may act as an oncogene via E2F pathway activation. | PMID: 23455423; COSMIC |
| Lung cancer | Upregulation in non-small cell lung cancer correlates with poor prognosis; CDCA4 silencing reduces cell viability. | PMID: 29187742; COSMIC |
| Colorectal cancer | CDCA4 is overexpressed and associated with advanced tumor stage; knockdown induces cell cycle arrest. | PMID: 30131756; COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 15.2 | Medium |
| Bone marrow | 10.8 | Medium |
| Lymph node | 8.5 | Low |
| Breast | 4.3 | Low |
| Lung | 3.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 12.5 | Cervical cancer cell line |
| A549 | 9.8 | Lung cancer cell line |
| MCF7 | 7.2 | Breast cancer cell line |
| HCT116 | 6.5 | Colorectal cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.287A>G (p.Asn96Ser) | Missense | <0.1% | Unknown functional impact; reported in COSMIC |
| c.412C>T (p.Arg138Trp) | Missense | <0.1% | Located in DNA-binding domain; potential loss of function |
| c.523_524insA | Frameshift | <0.1% | Predicted to cause protein truncation; likely loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense mutations in CDCA4 are predicted to result in truncated protein lacking functional domains, leading to loss of transcriptional regulatory activity.
Gain of Function (GOF)
Missense mutations in the DNA-binding domain may alter target gene specificity, potentially enhancing oncogenic activity.
Dominant Negative (DN)
No dominant-negative mutations have been characterized for CDCA4.
View complete mutation data：
Gene Ontology (GO)
| • DNA-binding transcription factor activity | • cell cycle |
| • G1/S transition of mitotic cell cycle | • regulation of transcription by RNA polymerase II |
| • nucleus | • protein binding |
Pathways
• E2F transcription factor network
• Cell cycle (G1/S phase)
• p53 signaling pathway (indirect)
Protein Summary
CDCA4 encodes a 241-amino acid protein containing a DNA-binding domain and a transactivation domain. It functions as a transcription factor that regulates genes involved in cell cycle progression, particularly at the G1/S checkpoint. The protein interacts with E2F1 and RB1, modulating transcriptional activity. CDCA4 is localized to the nucleus and is expressed in proliferating tissues. Its overexpression in multiple cancer types suggests a role in tumorigenesis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CDCA4 Knockout HEK293 Cell Line | EDJ-KQ3636 | Human | 55038 | Details Get a Quote |
| CDCA4 Knockout A-549 Cell Line | EDJ-KQ24209 | Human | 55038 | Details Get a Quote |
| CDCA4 Knockout HCT 116 Cell Line | EDJ-KQ25583 | Human | 55038 | Details Get a Quote |
| CDCA4 Knockout HeLa Cell Line | EDJ-KQ25584 | Human | 55038 | Details Get a Quote |
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