CDCA2: Cell Division Cycle Associated 2
A key regulator of mitotic progression and genomic stability, implicated in cancer pathogenesis.
Gene Information Card
| Symbol | CDCA2 |
|---|---|
| Full Name | Cell Division Cycle Associated 2 |
| Gene Type | Protein coding |
| Chromosomal Location | 8p21.2 |
| NCBI Gene ID | 157313 ncbi.nlm.nih.gov/gene/157313 |
| Ensembl ID | ENSG00000147400 |
| UniProt ID | Q69YH5 |
| OMIM ID | 609977 |
| HGNC ID | 23620 |
| Aliases | Repoman, FLJ10713 |
Description
CDCA2 (Cell Division Cycle Associated 2) encodes a protein that functions as a targeting subunit for protein phosphatase 1 (PP1). It is essential for mitotic progression, specifically for the dephosphorylation of mitotic substrates and the maintenance of genomic stability. CDCA2 localizes to the nucleus and is involved in chromosome segregation and cytokinesis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast Cancer | Overexpression of CDCA2 is associated with poor prognosis; may promote cell proliferation and migration via PP1 targeting. | PMID: 25652263 |
| Lung Cancer | Upregulated in non-small cell lung cancer; contributes to tumor growth and resistance to apoptosis. | PMID: 28209938 |
| Hepatocellular Carcinoma | High CDCA2 expression correlates with advanced stage and metastasis; involved in cell cycle dysregulation. | PMID: 29367642 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Bone Marrow | 8.2 | Low |
| Lymph Node | 6.1 | Low |
| Brain | 2.3 | Not detected |
| Heart | 1.8 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 15.4 | Cervical cancer cell line; high expression |
| A549 | 10.2 | Lung adenocarcinoma cell line; moderate expression |
| MCF7 | 9.8 | Breast cancer cell line; moderate expression |
| HEK293 | 4.5 | Embryonic kidney; low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1012C>T (p.Arg338Trp) | Missense | <0.1% | Unknown functional impact; reported in COSMIC |
| c.1456G>A (p.Glu486Lys) | Missense | <0.1% | Unknown functional impact; reported in COSMIC |
| c.1789_1790insA (p.Thr597Asnfs*5) | Frameshift | <0.1% | Predicted loss of function; truncation |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations leading to premature stop codons are predicted to cause loss of function, impairing mitotic progression.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in CDCA2.
Dominant Negative (DN)
No evidence for dominant-negative mutations in CDCA2.
View complete mutation data：
Gene Ontology (GO)
| • protein binding (GO:0005515) | • protein phosphatase binding (GO:0019903) |
| • nucleus (GO:0005634) | • mitotic nuclear division (GO:0007067) |
| • cell division (GO:0051301) | • mitotic cytokinesis (GO:0000281) |
Pathways
• Cell Cycle
• Mitotic (Reactome: R-HSA-69278)
• PP1-mediated dephosphorylation of mitotic substrates (Reactome: R-HSA-8852276)
Protein Summary
The CDCA2 protein, also known as Repo-Man (Recruits PP1 onto mitotic chromatin at anaphase), is a 797-amino acid nuclear protein. It contains a PP1-binding motif and a chromatin-targeting domain. During mitosis, CDCA2 recruits PP1 to dephosphorylate histone H3 and other mitotic substrates, facilitating chromosome decondensation and nuclear envelope reassembly. It is essential for proper mitotic exit and genomic stability.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CDCA2 Knockout HEK293 Cell Line | EDJ-KQ12837 | Human | 157313 | Details Get a Quote |
| CDCA2 Knockout A-549 Cell Line | EDJ-KQ41981 | Human | 157313 | Details Get a Quote |
| CDCA2 Knockout HCT 116 Cell Line | EDJ-KQ41982 | Human | 157313 | Details Get a Quote |
| CDCA2 Knockout HeLa Cell Line | EDJ-KQ41983 | Human | 157313 | Details Get a Quote |
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