CDC20B: Cell Division Cycle 20B, a Regulator of Mitotic Exit
Comprehensive genomic and functional analysis of CDC20B, a paralog of CDC20 involved in cell cycle control and anaphase promotion.
Gene Information Card
| Symbol | CDC20B |
|---|---|
| Full Name | Cell Division Cycle 20B |
| Gene Type | Protein-coding |
| Chromosomal Location | 5q11.2 |
| NCBI Gene ID | 348808 ncbi.nlm.nih.gov/gene/348808 |
| Ensembl ID | ENSG00000164171 |
| UniProt ID | Q8IYX8 |
| OMIM ID | 615378 |
| HGNC ID | 28178 |
| Aliases | bA364G4.1, CDC20 homolog B |
Description
CDC20B (Cell Division Cycle 20B) is a protein-coding gene located on chromosome 5q11.2. It encodes a protein that is a paralog of CDC20, a well-known activator of the anaphase-promoting complex/cyclosome (APC/C). CDC20B is thought to play a role in mitotic exit and cell cycle regulation by promoting the ubiquitination and degradation of securin and cyclin B. Its expression is enriched in testis and certain cancer cell lines, suggesting a potential role in germ cell development and oncogenesis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (general) | Dysregulation of APC/C activators can lead to aneuploidy and tumorigenesis; CDC20B overexpression observed in some cancers. | NCBI Gene, COSMIC |
| Male infertility | Testis-enriched expression suggests a role in spermatogenesis; variants may impair mitotic progression in germ cells. | UniProt, NCBI Gene |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Bone marrow | 3.2 | Low |
| Lymph node | 2.1 | Low |
| Spleen | 1.8 | Low |
| Brain | 0.5 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 8.4 | Moderate expression |
| HeLa | 6.1 | Moderate expression |
| K562 | 4.3 | Low expression |
| A549 | 3.0 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.101C>T (p.Thr34Met) | Missense | <0.1% | Unknown functional impact; rare population variant |
| c.457G>A (p.Val153Ile) | Missense | <0.1% | Predicted benign by in silico tools |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in CDC20B.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations described.
View complete mutation data：
Gene Ontology (GO)
| • anaphase-promoting complex (GO:0005680) | • anaphase-promoting complex activator activity (GO:0010997) |
| • cell division (GO:0051301) | • cell cycle (GO:0007049) |
| • protein binding (GO:0005515) |
Pathways
• Cell Cycle
• Mitotic (Reactome: R-HSA-69278)
• APC/C-mediated degradation of cell cycle proteins (Reactome: R-HSA-174178)
Protein Summary
The CDC20B protein (UniProt Q8IYX8) is a 507-amino acid protein containing seven WD40 repeats, which mediate protein-protein interactions. It is predicted to function as an activator of the anaphase-promoting complex/cyclosome (APC/C), similar to CDC20 and CDH1. CDC20B is localized to the nucleus and cytoplasm and is expressed at low levels in most tissues, with highest abundance in testis. Its precise role in cell cycle control remains under investigation, but it is thought to contribute to mitotic exit and chromosome segregation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CDC20B Knockout HEK293 Cell Line | EDJ-KQ12835 | Human | 166979 | Details Get a Quote |
| CDC20B Knockout HeLa Cell Line | EDJ-KQ58900 | Human | 166979 | Details Get a Quote |
| CDC20B Knockout A-549 Cell Line | EDJ-KQ67389 | Human | 166979 | Details Get a Quote |
| CDC20B Knockout HCT 116 Cell Line | EDJ-KQ75782 | Human | 166979 | Details Get a Quote |
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