CCT7: Chaperonin Containing TCP1 Subunit 7
A key component of the eukaryotic cytosolic chaperonin complex involved in protein folding and cellular homeostasis.
Gene Information Card
| Symbol | CCT7 |
|---|---|
| Full Name | Chaperonin Containing TCP1 Subunit 7 |
| Gene Type | Protein coding |
| Chromosomal Location | 2p13.2 |
| NCBI Gene ID | 10574 ncbi.nlm.nih.gov/gene/10574 |
| Ensembl ID | ENSG00000135624 |
| UniProt ID | Q99832 |
| OMIM ID | 605148 |
| HGNC ID | 1616 |
| Aliases | CCTeta, CCTH, TCP1-eta |
Description
CCT7 encodes a subunit of the eukaryotic cytosolic chaperonin complex (CCT/TRiC), which is essential for the ATP-dependent folding of proteins including actin, tubulin, and other cytosolic targets. The CCT complex consists of eight distinct subunits (CCT1-8), each contributing to the substrate-binding chamber. CCT7 (eta subunit) is involved in substrate recognition and ATP hydrolysis. The gene is ubiquitously expressed and its dysregulation has been implicated in cancer and neurodegenerative disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Altered CCT7 expression may affect protein folding homeostasis, promoting cell proliferation and survival. | COSMIC; literature |
| Neurodegenerative disorders | Impaired chaperonin function may lead to protein aggregation and cellular stress. | Literature; UniProt |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 28.5 | High |
| Brain | 18.2 | Medium |
| Liver | 15.0 | Medium |
| Heart | 12.8 | Medium |
| Lung | 10.5 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 22.3 | Cervical cancer cell line |
| HEK293 | 19.7 | Embryonic kidney cells |
| K562 | 15.4 | Leukemia cell line |
| HepG2 | 14.1 | Liver cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234A>G (p.Lys412Glu) | Missense | <0.1% | Unknown functional impact; reported in COSMIC |
| c.567C>T (p.Arg189Trp) | Missense | <0.1% | Reported in cancer samples; potential loss of function |
Mutation functional classification
Loss of Function (LOF)
Missense mutations may impair ATPase activity or substrate binding, reducing chaperonin efficiency.
Gain of Function (GOF)
Not reported.
Dominant Negative (DN)
Mutations in one subunit may disrupt the entire CCT complex, leading to dominant-negative effects on protein folding.
View complete mutation data：
Gene Ontology (GO)
| • protein folding | • ATP binding |
| • chaperonin-containing T-complex | • cytosol |
| • tubulin folding | • actin folding |
Pathways
• Protein processing in endoplasmic reticulum
• Chaperonin-mediated protein folding
Protein Summary
CCT7 is a 60 kDa protein that forms part of the hetero-oligomeric CCT/TRiC complex. It contains an ATP-binding domain and interacts with unfolded polypeptides to facilitate their correct folding in an ATP-dependent manner. The protein is highly conserved across eukaryotes and is essential for cell viability.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID |
|---|
